INTRODUCTION: The purpose of this study is to evaluate the clinical presentation of accidental dextromethorphan (DXM) ingestions in children <5 years old. Two consecutive years of poison center patient encounters were reviewed. Data including age, outcomes, amount of DXM ingested, co-ingestions, vital signs, clinical manifestations, hospital admissions, and mortality were abstracted. Data were analyzed using descriptive statistics. DISCUSSION: A total of 304 cases were identified with a mean age of 28.2 months (72% were > or =23 months). All cases co-ingested other products of over-the-counter cough and cold medications (i.e., acetaminophen, pseudoephedrine, guaifenesin, ibuprofen, various H1 receptor antagonists, and very infrequently ethanol). The mean DXM dose ingested was 35.0 mg (2.64 mg/kg). Of the patients, 62 (20.4%) experienced lethargy as the sole neurological sign and no patient had any cardiovascular abnormalities. Only 1 (13-monthold) patient, who ingested 3.2 mg/kg and presented with lethargy, was hospitalized and subsequently discharged 14 hours later. No deaths were recorded. CONCLUSION: As demonstrated in our patient population, accidental ingestions of DXM in the pediatric patient did well with supportive care alone and rarely required inpatient treatment.
INTRODUCTION: The purpose of this study is to evaluate the clinical presentation of accidental dextromethorphan (DXM) ingestions in children <5 years old. Two consecutive years of poison center patient encounters were reviewed. Data including age, outcomes, amount of DXM ingested, co-ingestions, vital signs, clinical manifestations, hospital admissions, and mortality were abstracted. Data were analyzed using descriptive statistics. DISCUSSION: A total of 304 cases were identified with a mean age of 28.2 months (72% were > or =23 months). All cases co-ingested other products of over-the-counter cough and cold medications (i.e., acetaminophen, pseudoephedrine, guaifenesin, ibuprofen, various H1 receptor antagonists, and very infrequently ethanol). The mean DXM dose ingested was 35.0 mg (2.64 mg/kg). Of the patients, 62 (20.4%) experienced lethargy as the sole neurological sign and no patient had any cardiovascular abnormalities. Only 1 (13-monthold) patient, who ingested 3.2 mg/kg and presented with lethargy, was hospitalized and subsequently discharged 14 hours later. No deaths were recorded. CONCLUSION: As demonstrated in our patient population, accidental ingestions of DXM in the pediatric patient did well with supportive care alone and rarely required inpatient treatment.
Authors: Ian M Paul; Michele L Shaffer; Katharine E Yoder; Sarah A Sturgis; Mark S Baker; Cheston M Berlin Journal: Clin Ther Date: 2004-09 Impact factor: 3.393