OBJECTIVE: Most epidemiological studies of the association between breast cancer risk and exposure to organochlorine pesticides or polychlorinated biphenyls (PCBs), which are suspected endocrine disrupters and potential risk factors for human breast cancer, have been conducted in western countries, and the majority of results have been null and the rest inconsistent. Here, we examined these associations in Japanese women in the largest study in Asian women to date. METHODS: The study was a matched case-control study of breast cancer with 403 eligible matched pairs from May 2001 to September 2005 at four hospitals in Nagano Prefecture, Japan. MEASUREMENTS: Serum samples were measured for PCBs and nine pesticide-related organochlorines, including dichlorodiphenyltrichloroethane (DDT). Odds ratios of breast cancer or its hormone-receptor-defined subtypes according to serum organochlorines were calculated. RESULTS: No increase in the risk of breast cancer was seen among women with higher serum concentrations of any organochlorine: o,p'-DDT, p,p'-DDT, p,p'-dichlorodiphenyldichloroethylene, hexachlorobenzene, beta-hexachlorocyclohexane, trans-nonachlor, cis-nonachlor, oxychlordane, mirex, or PCBs. Rather, higher serum levels of cis-nonachlor, mirex, or total PCBs were associated with a decreased risk of breast cancer CONCLUSIONS: Overall, these results suggest that breast cancer risk in Japan, a low-incidence country, is similar to that in western countries in terms of organochlorine exposure.
OBJECTIVE: Most epidemiological studies of the association between breast cancer risk and exposure to organochlorine pesticides or polychlorinated biphenyls (PCBs), which are suspected endocrine disrupters and potential risk factors for humanbreast cancer, have been conducted in western countries, and the majority of results have been null and the rest inconsistent. Here, we examined these associations in Japanese women in the largest study in Asian women to date. METHODS: The study was a matched case-control study of breast cancer with 403 eligible matched pairs from May 2001 to September 2005 at four hospitals in Nagano Prefecture, Japan. MEASUREMENTS: Serum samples were measured for PCBs and nine pesticide-related organochlorines, including dichlorodiphenyltrichloroethane (DDT). Odds ratios of breast cancer or its hormone-receptor-defined subtypes according to serum organochlorines were calculated. RESULTS: No increase in the risk of breast cancer was seen among women with higher serum concentrations of any organochlorine: o,p'-DDT, p,p'-DDT, p,p'-dichlorodiphenyldichloroethylene, hexachlorobenzene, beta-hexachlorocyclohexane, trans-nonachlor, cis-nonachlor, oxychlordane, mirex, or PCBs. Rather, higher serum levels of cis-nonachlor, mirex, or total PCBs were associated with a decreased risk of breast cancer CONCLUSIONS: Overall, these results suggest that breast cancer risk in Japan, a low-incidence country, is similar to that in western countries in terms of organochlorine exposure.
Authors: J A Rusiecki; H Denic-Roberts; C Byrne; J Cash; C F Raines; L A Brinton; S H Zahm; T Mason; M R Bonner; A Blair; R Hoover Journal: Environ Res Date: 2019-12-26 Impact factor: 6.498
Authors: Wei Zheng; Ben Zhang; Qiuyin Cai; Hyuna Sung; Kyriaki Michailidou; Jiajun Shi; Ji-Yeob Choi; Jirong Long; Joe Dennis; Manjeet K Humphreys; Qin Wang; Wei Lu; Yu-Tang Gao; Chun Li; Hui Cai; Sue K Park; Keun-Young Yoo; Dong-Young Noh; Wonshik Han; Alison M Dunning; Javier Benitez; Daniel Vincent; Francois Bacot; Daniel Tessier; Sung-Won Kim; Min Hyuk Lee; Jong Won Lee; Jong-Young Lee; Yong-Bing Xiang; Ying Zheng; Wenjin Wang; Bu-Tian Ji; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Hideo Tanaka; Anna H Wu; Chiu-chen Tseng; David Van Den Berg; Daniel O Stram; Soo Hwang Teo; Cheng Har Yip; In Nee Kang; Tien Y Wong; Chen-Yang Shen; Jyh-Cherng Yu; Chiun-Sheng Huang; Ming-Feng Hou; Mikael Hartman; Hui Miao; Soo Chin Lee; Thomas Choudary Putti; Kenneth Muir; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Suleeporn Sangrajrang; Hongbing Shen; Kexin Chen; Pei-Ei Wu; Zefang Ren; Christopher A Haiman; Aiko Sueta; Mi Kyung Kim; Ui Soon Khoo; Motoki Iwasaki; Paul D P Pharoah; Wanqing Wen; Per Hall; Xiao-Ou Shu; Douglas F Easton; Daehee Kang Journal: Hum Mol Genet Date: 2013-03-27 Impact factor: 6.150