Literature DB >> 19030974

Arthritis induced by adjuvant in spontaneously hypertensive and normotensive rats: endogenous glucocorticoid effects on inflammatory response.

Micheli G Torres1, Fabio H Kwasniewski, Luís G Scaliante, Emy L Ishii-Iwamoto, Silvana M Caparroz-Assef, Roberto K N Cuman, Ciomar A Bersani-Amado.   

Abstract

The present study investigated arthritis induced by complete Freund adjuvant (AIA) in spontaneously hypertensive and normotensive rats (respectively, SHR and NTR rats). The inflammatory reaction was studied for 28 days by evaluating paw edema and secondary lesions found 10 days after complete Freund adjuvant (CFA) administration. The body weight of the animals and macroscopic alterations of several organs, including spleen, thymus, adrenal glands, and lymph nodes, were also analyzed. The results showed that the AIA manifestations were decreased in SHRs compared with NTRs. Moreover, this altered inflammatory response was not modified by surgical adrenalectomy.

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Year:  2009        PMID： 19030974     DOI： 10.1007/s10753-008-9098-7

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  25 in total

1.  Endogenous nitric oxide does not modulate mesenteric mast cell degranulation in rats.

Authors:  Fábio H Kwasniewski; Wothan Tavares de Lima; Y S Bakhle; Sonia Jancar
Journal:  Biochem Pharmacol       Date:  2003-06-15       Impact factor: 5.858

2.  PATHOLOGICAL STUDIES ON THE ENDOCRINE ORGANS OF THE SPONTANEOUSLY HYPERTENSIVE RATS.

Authors:  K AOKI; H TANKAWA; T FUJINAMI; A MIYAZAKI; Y HASHIMOTO
Journal:  Jpn Heart J       Date:  1963-09

3.  Acute immune and non-immune inflammatory response in spontaneously hypertensive rats and normotensive rats. Role of endogenous nitric oxide.

Authors:  A A Ferreira; F H Kwasniewski; T C Delani; M G Torres; M A Silva; S M Caparroz-Assef; R K N Cuman; C A Bersani-Amado
Journal:  Inflammation       Date:  2007-07-31       Impact factor: 4.092

4.  Impairment in connective tissue mast cells degranulation in spontaneously hypertensive rats: stimulus dependent resistance.

Authors:  F H Kwasniewski; W Tavares de Lima; Y S Bakhle; S Jancar
Journal:  Br J Pharmacol       Date:  1998-06       Impact factor: 8.739

5.  The mast cell in early rat adjuvant arthritis.

Authors:  A Gryfe; P M Sanders; D L Gardner
Journal:  Ann Rheum Dis       Date:  1971-01       Impact factor: 19.103

Review 6.  Adjuvant induced polyarthritis - an overview.

Authors:  R T Owen
Journal:  Methods Find Exp Clin Pharmacol       Date:  1980-08

Review 7.  Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti-rheumatic therapy.

Authors:  Kari K Eklund
Journal:  Immunol Rev       Date:  2007-06       Impact factor: 12.988

8.  Different strains of rats develop different clinical forms of adjuvant disease.

Authors:  V Y Muir; D C Dumonde
Journal:  Ann Rheum Dis       Date:  1982-10       Impact factor: 19.103

9.  Bronchoconstriction and endogenous nitric oxide in isolated lungs of spontaneously hypertensive rats.

Authors:  Fábio H Kwasniewski; Richardt Gama Landgraf; Yeshwant S Bakhle; Sonia Jancar
Journal:  Eur J Pharmacol       Date:  2004-03-19       Impact factor: 4.432

10.  The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat.

Authors:  Silvana M Caparroz-Assef; Ciomar A Bersani-Amado; Ana M Kelmer-Bracht; Adelar Bracht; Emy L Ishii-Iwamoto
Journal:  Mol Cell Biochem       Date:  2007-03-09       Impact factor: 3.396
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  2 in total

1.  Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids.

Authors:  Guang Qiu; Edward L Spangler; Ruiqian Wan; Marshall Miller; Mark P Mattson; Kwok-Fai So; Rafael de Cabo; Sige Zou; Donald K Ingram
Journal:  Neurobiol Aging       Date:  2012-01-05       Impact factor: 4.673

2.  Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits of Pterodon pubescens Benth in Acute and Chronic Inflammation.

Authors:  Jaqueline Hoscheid; Ciomar Aparecida Bersani-Amado; Bruno Ambrósio da Rocha; Priscila Miyuki Outuki; Maria Angélica Raffaini Cóvas Pereira da Silva; Diego Lacir Froehlich; Mara Lane Carvalho Cardoso
Journal:  Evid Based Complement Alternat Med       Date:  2013-07-21       Impact factor: 2.629
  2 in total

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