OBJECTIVE: To assess which measurements best predict improvement on ADHD symptomatology after medication is given. METHODS:147 children aged 6 to 12 years, diagnosed with ADHD, participated in a double-blind placebo controlled twoweek crossover trial of methylphenidate. RESULTS: There were statistically significant differences on all measures between placebo and medication. Effect size for the overall group was 0.33 (CGI-P), 0.80 (CGI-T), 1.33 (CGI), 0.56 (CPT), 0.82 (RASS). CONCLUSIONS:Acute behavioural response measures, where children are observed by clinicians (RASS and CGI), were overall more reliable than parent reports in detecting improvement on ADHD symptomatology. Teacher reports were also very important, especially in the 9 to 12 year old group.
RCT Entities:
OBJECTIVE: To assess which measurements best predict improvement on ADHD symptomatology after medication is given. METHODS: 147 children aged 6 to 12 years, diagnosed with ADHD, participated in a double-blind placebo controlled twoweek crossover trial of methylphenidate. RESULTS: There were statistically significant differences on all measures between placebo and medication. Effect size for the overall group was 0.33 (CGI-P), 0.80 (CGI-T), 1.33 (CGI), 0.56 (CPT), 0.82 (RASS). CONCLUSIONS: Acute behavioural response measures, where children are observed by clinicians (RASS and CGI), were overall more reliable than parent reports in detecting improvement on ADHD symptomatology. Teacher reports were also very important, especially in the 9 to 12 year old group.
Authors: B Vitiello; J B Severe; L L Greenhill; L E Arnold; H B Abikoff; O G Bukstein; G R Elliott; L Hechtman; P S Jensen; S P Hinshaw; J S March; J H Newcorn; J M Swanson; D P Cantwell Journal: J Am Acad Child Adolesc Psychiatry Date: 2001-02 Impact factor: 8.829
Authors: B B Lahey; B Applegate; K McBurnett; J Biederman; L Greenhill; G W Hynd; R A Barkley; J Newcorn; P Jensen; J Richters Journal: Am J Psychiatry Date: 1994-11 Impact factor: 18.112
Authors: Daniel Y Lin; Christopher J Kratochvil; Wen Xu; Ling Jin; Deborah N D'Souza; William Kielbasa; Albert J Allen Journal: J Child Adolesc Psychopharmacol Date: 2014-05 Impact factor: 2.576
Authors: Ole Jakob Storebø; Erica Ramstad; Helle B Krogh; Trine Danvad Nilausen; Maria Skoog; Mathilde Holmskov; Susanne Rosendal; Camilla Groth; Frederik L Magnusson; Carlos R Moreira-Maia; Donna Gillies; Kirsten Buch Rasmussen; Dorothy Gauci; Morris Zwi; Richard Kirubakaran; Bente Forsbøl; Erik Simonsen; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2015-11-25