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Literature DB >> 19029995

A case of hearing loss associated with pegylated interferon and ribavirin treatment ameliorated by prednisone.

Abstract

BACKGROUND: A 51-year-old white man with chronic obstructive pulmonary disease who was infected with HCV genotype 2b presented with sudden left-sided hearing loss. He had been taking pegylated interferon (PEG-IFN) and ribavirin treatment for 6 weeks without any notable adverse effects. He had also been taking naproxen for 2 years for the treatment of chronic back pain. INVESTIGATIONS: Physical examination, laboratory tests, including complete blood counts and liver function tests, otoscopic examination, audiogram, MRI of the middle ear, objective causality assessment using the Naranjo probability scale. DIAGNOSIS: PEG-IFN-induced acute sensorineural hearing loss. MANAGEMENT: Prednisone while maintaining treatment with PEG-IFN.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2008 PMID： 19029995 DOI： 10.1038/ncpgasthep1317

Source DB: PubMed Journal: Nat Clin Pract Gastroenterol Hepatol ISSN： 1743-4378

17 in total

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3 in total