Literature DB >> 19029912

Recurrent chromosomal abnormalities in human embryonic stem cells.

Claudia Spits1, Ileana Mateizel, Mieke Geens, Afroditi Mertzanidou, Catherine Staessen, Yves Vandeskelde, Josiane Van der Elst, Inge Liebaers, Karen Sermon.   

Abstract

Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.

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Year:  2008        PMID： 19029912     DOI： 10.1038/nbt.1510

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  96 in total

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