PURPOSE: TMPRSS2-ERG gene fusion was recently reported as the most common gene rearrangement in prostate cancer (PCA). RESULTS: In this cohort 41% of the patients showed positive gene fusion status in their PCA. The TMPRSS2-ERG gene fusion status was homogenous within the same cancer focus and 82% of fusion positive PCA were present in GS 6 or 7 vs. 14% in GS 8 (p = 0.004). Moreover, TMPRSS2-ERG fusion was present in 42% of Gleason pattern 3 vs. 27% of Gleason pattern 4 (p = 0.014). However, in this study, no significant association was noticed between TMPRSS2-ERG fusion status in relation to pathological stage, surgical margin or biochemical failure. EXPERIMENTAL DESIGN: Using break-apart FISH assay to indirectly assess the fusion of TMPRSS2-ERG. We sought to characterize the incidence, pathological features and clinical parameters of TMPRSS2-ERG gene fusion in a cohort of 196 Canadian men treated by radical prostatectomy for localized PCA, and to investigate its potential as a biomarker in PCA. CONCLUSION: The higher association of TMPRSS2-ERG with Gleason score 6 and 7 should be further investigated. If confirmed, this could have significant clinical impact in further stratifying patients with PCA should the TMPRSS2-ERG be confirmed as a prognostic biomarker.
PURPOSE:TMPRSS2-ERG gene fusion was recently reported as the most common gene rearrangement in prostate cancer (PCA). RESULTS: In this cohort 41% of the patients showed positive gene fusion status in their PCA. The TMPRSS2-ERG gene fusion status was homogenous within the same cancer focus and 82% of fusion positive PCA were present in GS 6 or 7 vs. 14% in GS 8 (p = 0.004). Moreover, TMPRSS2-ERG fusion was present in 42% of Gleason pattern 3 vs. 27% of Gleason pattern 4 (p = 0.014). However, in this study, no significant association was noticed between TMPRSS2-ERG fusion status in relation to pathological stage, surgical margin or biochemical failure. EXPERIMENTAL DESIGN: Using break-apart FISH assay to indirectly assess the fusion of TMPRSS2-ERG. We sought to characterize the incidence, pathological features and clinical parameters of TMPRSS2-ERG gene fusion in a cohort of 196 Canadian men treated by radical prostatectomy for localized PCA, and to investigate its potential as a biomarker in PCA. CONCLUSION: The higher association of TMPRSS2-ERG with Gleason score 6 and 7 should be further investigated. If confirmed, this could have significant clinical impact in further stratifying patients with PCA should the TMPRSS2-ERG be confirmed as a prognostic biomarker.
Authors: Raymond B Nagle; Amit M Algotar; Connie C Cortez; Katherine Smith; Carol Jones; Ubaradka G Sathyanarayana; Steven Yun; Janice Riley; Dea Nagy; Ryan Dittamore; Bruce Dalkin; Laura Brosh; Gary Pestano Journal: Prostate Date: 2013-05-07 Impact factor: 4.104
Authors: Andreas Pettersson; Rebecca E Graff; Scott R Bauer; Michael J Pitt; Rosina T Lis; Edward C Stack; Neil E Martin; Lauren Kunz; Kathryn L Penney; Azra H Ligon; Catherine Suppan; Richard Flavin; Howard D Sesso; Jennifer R Rider; Christopher Sweeney; Meir J Stampfer; Michelangelo Fiorentino; Philip W Kantoff; Martin G Sanda; Edward L Giovannucci; Eric L Ding; Massimo Loda; Lorelei A Mucci Journal: Cancer Epidemiol Biomarkers Prev Date: 2012-06-26 Impact factor: 4.254
Authors: Samson W Fine; Anuradha Gopalan; Margaret A Leversha; Hikmat A Al-Ahmadie; Satish K Tickoo; Qin Zhou; Jaya M Satagopan; Peter T Scardino; William L Gerald; Victor E Reuter Journal: Mod Pathol Date: 2010-06-18 Impact factor: 7.842
Authors: Anuradha Gopalan; Margaret A Leversha; Maria E Dudas; Alexandra C Maschino; Jeremy Chang; Hikmat A Al-Ahmadie; Ying-Bei Chen; Satish K Tickoo; Victor E Reuter; Samson W Fine Journal: Histopathology Date: 2013-05-23 Impact factor: 5.087
Authors: Martine P Roudier; Brian R Winters; Ilsa Coleman; Hung-Ming Lam; Xiaotun Zhang; Roger Coleman; Lisly Chéry; Lawrence D True; Celestia S Higano; Bruce Montgomery; Paul H Lange; Linda A Snyder; Shiv Srivastava; Eva Corey; Robert L Vessella; Peter S Nelson; Aykut Üren; Colm Morrissey Journal: Prostate Date: 2016-03-16 Impact factor: 4.104