PURPOSE: To evaluate the ability of scanning laser polarimetry with variable corneal compensation to detect progressive retinal nerve fiber layer (RNFL) loss in glaucoma patients and patients suspected of having the disease. METHODS: This was an observational cohort study that included 335 eyes of 195 patients. Images were obtained annually with the GDx VCC scanning laser polarimeter, along with optic disc stereophotographs and standard automated perimetry (SAP) visual fields. The median follow-up time was 3.94 years. Progression was determined using commercial software for SAP and by masked assessment of optic disc stereophotographs performed by expert graders. Random coefficient models were used to evaluate the relationship between RNFL thickness measurements over time and progression as determined by SAP and/or stereophotographs. RESULTS: From the 335 eyes, 34 (10%) showed progression over time by stereophotographs and/or SAP. Average GDx VCC measurements decreased significantly over time for both progressors as well as non-progressors. However, the rate of decline was significantly higher in the progressing group (-0.70 microm/year) compared to the non-progressing group (-0.14 microm/year; P=0.001). Black race and male sex were significantly associated with higher rates of RNFL loss during follow-up. CONCLUSIONS: The GDx VCC scanning laser polarimeter was able to identify longitudinal RNFL loss in eyes that showed progression in optic disc stereophotographs and/or visual fields. These findings suggest that this technology could be useful to detect and monitor progressive disease in patients with established diagnosis of glaucoma or suspected of having the disease.
PURPOSE: To evaluate the ability of scanning laser polarimetry with variable corneal compensation to detect progressive retinal nerve fiber layer (RNFL) loss in glaucomapatients and patients suspected of having the disease. METHODS: This was an observational cohort study that included 335 eyes of 195 patients. Images were obtained annually with the GDx VCC scanning laser polarimeter, along with optic disc stereophotographs and standard automated perimetry (SAP) visual fields. The median follow-up time was 3.94 years. Progression was determined using commercial software for SAP and by masked assessment of optic disc stereophotographs performed by expert graders. Random coefficient models were used to evaluate the relationship between RNFL thickness measurements over time and progression as determined by SAP and/or stereophotographs. RESULTS: From the 335 eyes, 34 (10%) showed progression over time by stereophotographs and/or SAP. Average GDx VCC measurements decreased significantly over time for both progressors as well as non-progressors. However, the rate of decline was significantly higher in the progressing group (-0.70 microm/year) compared to the non-progressing group (-0.14 microm/year; P=0.001). Black race and male sex were significantly associated with higher rates of RNFL loss during follow-up. CONCLUSIONS: The GDx VCC scanning laser polarimeter was able to identify longitudinal RNFL loss in eyes that showed progression in optic disc stereophotographs and/or visual fields. These findings suggest that this technology could be useful to detect and monitor progressive disease in patients with established diagnosis of glaucoma or suspected of having the disease.
Authors: R C Wolfs; P H Borger; R S Ramrattan; C C Klaver; C A Hulsman; A Hofman; J R Vingerling; R A Hitchings; P T de Jong Journal: Invest Ophthalmol Vis Sci Date: 2000-10 Impact factor: 4.799
Authors: Michael A Kass; Dale K Heuer; Eve J Higginbotham; Chris A Johnson; John L Keltner; J Philip Miller; Richard K Parrish; M Roy Wilson; Mae O Gordon Journal: Arch Ophthalmol Date: 2002-06
Authors: Felipe A Medeiros; Gianmarco Vizzeri; Linda M Zangwill; Luciana M Alencar; Pamela A Sample; Robert N Weinreb Journal: Ophthalmology Date: 2008-01-22 Impact factor: 12.079
Authors: Christopher Kai-shun Leung; Carol Yim-lui Cheung; Dusheng Lin; Chi Pui Pang; Dennis S C Lam; Robert N Weinreb Journal: Invest Ophthalmol Vis Sci Date: 2008-06-06 Impact factor: 4.799
Authors: B'ann T Gabelt; Carol A Rasmussen; Ozan Y Tektas; Charlene B Y Kim; John C Peterson; T Michael Nork; James N Ver Hoeve; Elke Lütjen-Drecoll; Paul L Kaufman Journal: Invest Ophthalmol Vis Sci Date: 2012-04-30 Impact factor: 4.799
Authors: Felipe A Medeiros; Linda M Zangwill; Christopher A Girkin; Jeffrey M Liebmann; Robert N Weinreb Journal: Am J Ophthalmol Date: 2012-02-07 Impact factor: 5.258
Authors: Felipe A Medeiros; Linda M Zangwill; Christopher Bowd; Kaweh Mansouri; Robert N Weinreb Journal: Invest Ophthalmol Vis Sci Date: 2012-10-05 Impact factor: 4.799
Authors: Jane Z Kuo; Linda M Zangwill; Felipe A Medeiros; Jeffery M Liebmann; Christopher A Girkin; Na'ama Hammel; Jerome I Rotter; Robert N Weinreb Journal: Am J Ophthalmol Date: 2015-04-04 Impact factor: 5.258
Authors: Monica F Chen; Toco Y P Chui; Paula Alhadeff; Richard B Rosen; Robert Ritch; Alfredo Dubra; Donald C Hood Journal: Invest Ophthalmol Vis Sci Date: 2015-01-08 Impact factor: 4.799
Authors: Ting Liu; Andrew J Tatham; Carolina P B Gracitelli; Linda M Zangwill; Robert N Weinreb; Felipe A Medeiros Journal: Ophthalmology Date: 2015-09-15 Impact factor: 12.079
Authors: Linda M Zangwill; Sonia Jain; Keri Dirkes; Feng He; Felipe A Medeiros; Gary L Trick; James D Brandt; George A Cioffi; Anne L Coleman; Jeffrey M Liebmann; Jody R Piltz-Seymour; Mae O Gordon; Michael A Kass; Robert N Weinreb Journal: Am J Ophthalmol Date: 2013-03-14 Impact factor: 5.258
Authors: Renato Lisboa; Yeoun Sook Chun; Linda M Zangwill; Robert N Weinreb; Peter N Rosen; Jeffrey M Liebmann; Christopher A Girkin; Felipe A Medeiros Journal: JAMA Ophthalmol Date: 2013-04 Impact factor: 7.389