OBJECTIVE: To test whether there was a difference in serum retinol-binding protein 4 (RBP4) levels between subjects with polycystic ovary syndrome (PCOS) and those with a healthy regular menstrual cycle and, in addition, to correlate serum RBP4 levels with a variety of parameters. DESIGN: Clinical study. SETTING: University hospital. PATIENT(S): A total of 74 nonobese women were evaluated. Thirty-seven had PCOS, whereas the remaining 37 served as control subjects. INTERVENTION(S): Serum RBP4 levels were analyzed using ELISA. MAIN OUTCOME MEASURE(S): Serum levels of FSH, LH, TSH, E(2), T, insulin, glucose, cholesterol, triglycerides, and RBP4. RESULT(S): The women with PCOS had higher levels of serum RBP4, waist-to-hip ratio, LH, T, insulin, homeostatic model assessment of insulin resistance, cholesterol, and triglycerides. Logistic regression analyses revealed a significant association between odds ratio (OR) values of PCOS and both T (OR = 1.125; 95% confidence interval [CI] 1.050-1.205), and cholesterol levels (OR = 1.029; 95% CI 1.004-1.056). Age and triglycerides were significantly correlated to serum RBP4 levels by multiple linear regression analysis. CONCLUSION(S): Our study has shown that [1] elevated RBP4 levels might arise from triglyceride metabolism, and that RBP4 levels might not be influenced by PCOS itself. [2] RBP4 might not be a useful marker of insulin resistance in subjects with PCOS. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To test whether there was a difference in serum retinol-binding protein 4 (RBP4) levels between subjects with polycystic ovary syndrome (PCOS) and those with a healthy regular menstrual cycle and, in addition, to correlate serum RBP4 levels with a variety of parameters. DESIGN: Clinical study. SETTING: University hospital. PATIENT(S): A total of 74 nonobese women were evaluated. Thirty-seven had PCOS, whereas the remaining 37 served as control subjects. INTERVENTION(S): Serum RBP4 levels were analyzed using ELISA. MAIN OUTCOME MEASURE(S): Serum levels of FSH, LH, TSH, E(2), T, insulin, glucose, cholesterol, triglycerides, and RBP4. RESULT(S): The women with PCOS had higher levels of serum RBP4, waist-to-hip ratio, LH, T, insulin, homeostatic model assessment of insulin resistance, cholesterol, and triglycerides. Logistic regression analyses revealed a significant association between odds ratio (OR) values of PCOS and both T (OR = 1.125; 95% confidence interval [CI] 1.050-1.205), and cholesterol levels (OR = 1.029; 95% CI 1.004-1.056). Age and triglycerides were significantly correlated to serum RBP4 levels by multiple linear regression analysis. CONCLUSION(S): Our study has shown that [1] elevated RBP4 levels might arise from triglyceride metabolism, and that RBP4 levels might not be influenced by PCOS itself. [2] RBP4 might not be a useful marker of insulin resistance in subjects with PCOS. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Aviva B Sopher; Adrienne T Gerken; Eun-Ju Lee; William E Blaner; Stefanie Deeds; Dympna Gallagher; Dikoma C Shungu; Xiangling Mao; Abeer Hassoun; Donald J Mc Mahon; Sharon E Oberfield Journal: J Pediatr Endocrinol Metab Date: 2011 Impact factor: 1.634
Authors: Aviva B Sopher; Adrienne T Gerken; William S Blaner; Jeremy M Root; Donald J McMahon; Sharon E Oberfield Journal: Fertil Steril Date: 2012-02-17 Impact factor: 7.329