Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method.

Literature DB >> 19028105

Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method.

Takuya Arai¹, Ming-Rong Zhang, Masanao Ogawa, Toshimitsu Fukumura, Koichi Kato, Kazutoshi Suzuki.

Abstract

[1-(11)C]Acetyl chloride ([(11)C]AcCl), an important [(11)C]acylating agent, was synthesized by reacting [(11)C]CO(2) with methylmagnesium bromide coated on the inner surface of a polyethylene loop (loop method). By optimizing the reaction conditions and synthesis parameters, [1-(11)C]phenylacetate and [1-(11)C]benzylacetate were produced from [(11)C]AcCl in high radiochemical yield and specific activity.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 19028105 DOI： 10.1016/j.apradiso.2008.09.013

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

Keyword Cloud
Cited

2 in total

1. Synthesis of [¹¹C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([¹¹C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase.

Authors: Tomoteru Yamasaki; Katsushi Kumata; Atsuto Hiraishi; Yiding Zhang; Hidekatsu Wakizaka; Yusuke Kurihara; Nobuki Nengaki; Ming-Rong Zhang
Journal: EJNMMI Radiopharm Chem Date: 2022-03-15

2. Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

Authors: Christina Rami-Mark; Johanna Ungersboeck; Daniela Haeusler; Lukas Nics; Cecile Philippe; Markus Mitterhauser; Matthaeus Willeit; Rupert Lanzenberger; Georgios Karanikas; Wolfgang Wadsak
Journal: Appl Radiat Isot Date: 2013-08-03 Impact factor: 1.513

2 in total

Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method.

1. Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase.

2. Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

1. Synthesis of [¹¹C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([¹¹C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase.