| Literature DB >> 19027953 |
Kazue Ohishi1, Akiko Ando, Rintaro Suzuki, Kiyotaka Takishita, Masaru Kawato, Etsuko Katsumata, Dai Ohtsu, Kenji Okutsu, Koji Tokutake, Hirokazu Miyahara, Hirotaka Nakamura, Tsukasa Murayama, Tadashi Maruyama.
Abstract
Signaling lymphocyte activation molecule (SLAM) is thought to be a major cellular receptor for high-host specificity morbilliviruses, which cause devastating and highly infectious diseases in mammals. We determined the sequences of SLAM cDNA from five species of marine mammal, including two cetaceans, two pinnipeds and one sirenian, and generated three-dimensional models to understand the receptor-virus interaction. Twenty-one amino acid residues in the immunoglobulin-like V domains of the SLAMs were shown to bind the viral protein. Notably, the sequences from pinnipeds and dogs were highly homologous, which is consistent with the fact that canine distemper virus was previously shown to cause a mass die-off of seals. Among these twenty-one residues, eight (63, 66, 68, 72, 84, 119, 121 and 130) were shared by animal groups susceptible to a particular morbillivirus species. This set of residues appears to determine host-virus specificity and may be useful for risk estimation for morbilliviruses.Entities:
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Year: 2008 PMID： 19027953 DOI： 10.1016/j.cimid.2008.10.003
Source DB: PubMed Journal: Comp Immunol Microbiol Infect Dis ISSN： 0147-9571 Impact factor: 2.268