| Literature DB >> 19027297 |
Raed A Al-Qawasmeh1, Yoon Lee, Ming-Yu Cao, Xiaoping Gu, Stéphane Viau, Jeff Lightfoot, Jim A Wright, Aiping H Young.
Abstract
A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest.Entities:
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Year: 2008 PMID： 19027297 DOI： 10.1016/j.bmcl.2008.11.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823