| Literature DB >> 19026984 |
Kosuke Ebina1, Kazuya Oshima, Morihiro Matsuda, Atsunori Fukuhara, Kazuhisa Maeda, Shinji Kihara, Jun Hashimoto, Takahiro Ochi, Nirmal K Banda, Hideki Yoshikawa, Iichiro Shimomura.
Abstract
Adiponectin (APN) is a hormone released by adipose tissue with anti-inflammatory properties. The purpose of this study was to examine the therapeutic effects of systemic delivery of APN in murine arthritis model. Collagen-induced arthritis (CIA) was induced in male DBA1/J mice, and adenoviral vectors encoding human APN (Ad-APN) or beta-galactosidase (Ad-beta-gal) as control were injected either before or during arthritis progression. Systemic APN delivery at both time points significantly decreased clinical disease activity scores of CIA. In addition, APN treatment before arthritis progression significantly decreased histological scores of inflammation and cartilage damage, bone erosion, and mRNA levels of pro-inflammatory cytokines in the joints, without altering serum anti-collagen antibodies levels. Immunohistochemical staining showed significant inhibition of complement C1q and C3 deposition in the joints of Ad-APN infected CIA mice. These results provide novel evidence that systemic APN delivery prevents inflammation and joint destruction in murine arthritis model.Entities:
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Year: 2008 PMID： 19026984 DOI： 10.1016/j.bbrc.2008.11.005
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575