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Literature DB >> 19026774

DNA2 resolves expanding flap in mitochondrial base excision repair.

Abstract

In a recent issue of Molecular Cell, Zheng et al. (2008) demonstrated that human DNA2, originally identified in yeast as a nuclear DNA replication and repair factor, functions exclusively in mammalian mitochondria in the recently discovered long-patch base excision repair pathway.

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Year: 2008 PMID： 19026774 PMCID： PMC3967838 DOI： 10.1016/j.molcel.2008.11.007

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism.

Authors: Timothy A Brown; Ciro Cecconi; Ariana N Tkachuk; Carlos Bustamante; David A Clayton
Journal: Genes Dev Date: 2005-10-15 Impact factor: 11.361

Review 2. Inherited mitochondrial diseases of DNA replication.

Authors: William C Copeland
Journal: Annu Rev Med Date: 2008 Impact factor: 13.739

3. Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro.

Authors: M J Longley; R Prasad; D K Srivastava; S H Wilson; W C Copeland
Journal: Proc Natl Acad Sci U S A Date: 1998-10-13 Impact factor: 11.205

4. A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function.

Authors: M E Budd; J L Campbell
Journal: Mol Cell Biol Date: 1997-04 Impact factor: 4.272

5. Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.

Authors: Li Zheng; Mian Zhou; Zhigang Guo; Huiming Lu; Limin Qian; Huifang Dai; Junzhuan Qiu; Elena Yakubovskaya; Daniel F Bogenhagen; Bruce Demple; Binghui Shen
Journal: Mol Cell Date: 2008-11-07 Impact factor: 17.970

6. Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta.

Authors: Martin E Budd; Clara C Reis; Stephanie Smith; Kyungjae Myung; Judith L Campbell
Journal: Mol Cell Biol Date: 2006-04 Impact factor: 4.272

7. Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.

Authors: Mansour Akbari; Torkild Visnes; Hans E Krokan; Marit Otterlei
Journal: DNA Repair (Amst) Date: 2008-03-04

8. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.

Authors: Pingfang Liu; Limin Qian; Jung-Suk Sung; Nadja C de Souza-Pinto; Li Zheng; Daniel F Bogenhagen; Vilhelm A Bohr; David M Wilson; Binghui Shen; Bruce Demple
Journal: Mol Cell Biol Date: 2008-06-09 Impact factor: 4.272

9. Long patch base excision repair in mammalian mitochondrial genomes.

Authors: Bartosz Szczesny; Anne W Tann; Matthew J Longley; William C Copeland; Sankar Mitra
Journal: J Biol Chem Date: 2008-07-17 Impact factor: 5.157

10. Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone.

Authors: Mark Bowmaker; Ming Yao Yang; Takehiro Yasukawa; Aurelio Reyes; Howard T Jacobs; Joel A Huberman; Ian J Holt
Journal: J Biol Chem Date: 2003-09-23 Impact factor: 5.157

10 in total

31 in total

10. Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.

Authors: Lata Balakrishnan; Jason Stewart; Piotr Polaczek; Judith L Campbell; Robert A Bambara
Journal: J Biol Chem Date: 2009-12-17 Impact factor: 5.157

DNA2 resolves expanding flap in mitochondrial base excision repair.

1. Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism.

Review 2. Inherited mitochondrial diseases of DNA replication.

3. Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro.

4. A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function.

5. Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.

6. Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta.

7. Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.

8. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.

9. Long patch base excision repair in mammalian mitochondrial genomes.

10. Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone.

Review 1. Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations.

Review 2. Okazaki fragment maturation: nucleases take centre stage.

Review 3. Repair of persistent strand breaks in the mitochondrial genome.

Review 4. The role of DNA exonucleases in protecting genome stability and their impact on ageing.

5. Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.

6. Dna2 exhibits a unique strand end-dependent helicase function.

Review 7. Mechanism of homologous recombination and implications for aging-related deletions in mitochondrial DNA.

8. Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.

Review 9. The mitochondrial DNA polymerase in health and disease.

10. Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.