Zhen Yan1, Yi-Ming Wu, Yong-Jun Wu. 1. Department of Occupational Medicine, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Abstract
OBJECTIVE: To analyze the correlation between the polymorphism of CYP2D6*10 allele and the risk of lung cancer. METHODS: A case-control study was conducted among 118 lung cancer patients and 118 control subjects (matched for sex and age) to investigate the role of the single nucleotide polymorphism of C188T and G4268C in lung cancer using PCR-RFLP to identify the genotypes. Logistic regression was taken to analyze the relationship between genetic polymorphism and lung cancer susceptibility and evaluate the combined effect of genotypes and smoking. RESULTS: The non-T188/T genotype (including C188/C and C188/T genotype) or non-C4268/C genotype (including G4268/G and G4268/C genotype) was moderately correlated with lung cancer. After stratification analysis according to smoking, it revealed that non-T188/T or non-C4268/C genotype was associated with significantly increased risk in non-smokers and light-smokers subgroups; however, there was no interaction between non-T188/T or non-C4268/C genotype and smoking on susceptibility to lung cancer, neither between the two genotypes. CONCLUSION: T188/T or C4268/C genotype, as protective factors in non-smokers or light-smokers subgroups, may help decrease the susceptibility to lung cancer in these subjects.
OBJECTIVE: To analyze the correlation between the polymorphism of CYP2D6*10 allele and the risk of lung cancer. METHODS: A case-control study was conducted among 118 lung cancerpatients and 118 control subjects (matched for sex and age) to investigate the role of the single nucleotide polymorphism of C188T and G4268C in lung cancer using PCR-RFLP to identify the genotypes. Logistic regression was taken to analyze the relationship between genetic polymorphism and lung cancer susceptibility and evaluate the combined effect of genotypes and smoking. RESULTS: The non-T188/T genotype (including C188/C and C188/T genotype) or non-C4268/C genotype (including G4268/G and G4268/C genotype) was moderately correlated with lung cancer. After stratification analysis according to smoking, it revealed that non-T188/T or non-C4268/C genotype was associated with significantly increased risk in non-smokers and light-smokers subgroups; however, there was no interaction between non-T188/T or non-C4268/C genotype and smoking on susceptibility to lung cancer, neither between the two genotypes. CONCLUSION: T188/T or C4268/C genotype, as protective factors in non-smokers or light-smokers subgroups, may help decrease the susceptibility to lung cancer in these subjects.