| Literature DB >> 19023700 |
Anna Brillowska-Dabrowska1, T Schön, S Pannanusorn, N Lönnbro, L Bernhoff, J Bonnedal, J Haggstrom, A Wistedt, V Fernandez, M C Arendrup.
Abstract
In a haematology ward, Candida parapsilosis was found in blood cultures from 4 patients within a month. As C. parapsilosis is known to have a restricted genetic diversity, a combined methodological approach was adopted to establish a possible epidemiological relationship among the isolates (n = 9). Multilocus sequence typing and random amplified polymorphic DNA analysis suggested a clonal origin of the isolates. The clonal origin was confirmed by microsatellite analysis, a method that displayed the highest discriminatory level and readily differentiated cluster isolates from 2 epidemiologically unrelated strains of C. parapsilosis. The use of novel methods of genotyping such as microsatellite analysis will facilitate epidemiological investigations of potential clonal outbreaks of fungaemia.Entities:
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Year: 2009 PMID： 19023700 DOI： 10.1080/00365540802585301
Source DB: PubMed Journal: Scand J Infect Dis ISSN： 0036-5548