Literature DB >> 19023538

Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia.

Jung Ho Choi1, Mun-Chual Rho, Seung Woong Lee, Ji Na Choi, Koanhoi Kim, Gyu Young Song, Young Kook Kim.   

Abstract

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant inhibition of ACAT enzyme. Via bioactivity-guided fractionation of the ethanol extract of Psoralea corylifolia, two prenylated flavonoids were isolated. Their structures were determined as bavachin (1) and isobavachalcone (2) by spectroscopic analysis ((1)H-, (13)C-NMR, 2DNMR, and ESI-MS). The IC(50) values were 86.0 (1) and 48.0 (2) microM in the ACAT assay system using rat liver microsome. Compound 2 also decreased cholesteryl ester formations in HepG2 cells. In addition, this compound showed a noncompetitive type of inhibition of ACAT.

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Year:  2008        PMID： 19023538     DOI： 10.1007/s12272-001-2126-x

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  8 in total

Review 1.  Isobavachalcone: an overview.

Authors:  Victor Kuete; Louis P Sandjo
Journal:  Chin J Integr Med       Date:  2012-07-07       Impact factor: 1.978

2.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

3.  Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia.

Authors:  Joonwoo Park; Do Hee Kim; Hye-Na Ahn; Yun Seon Song; Young Joo Lee; Jae-Ha Ryu
Journal:  Biomol Ther (Seoul)       Date:  2012-03       Impact factor: 4.634

Review 4.  Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology.

Authors:  Bhupendra Koul; Pooja Taak; Arvind Kumar; Anil Kumar; Indraneel Sanyal
Journal:  J Ethnopharmacol       Date:  2018-12-03       Impact factor: 4.360

5.  Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells.

Authors:  Yang Li; Chunxia Xu; Jinjin Xu; Zifei Qin; Shishi Li; Liufang Hu; Zhihong Yao; Frank J Gonzalez; Xinsheng Yao
Journal:  J Pharm Pharmacol       Date:  2020-07-09       Impact factor: 4.810

Review 6.  Phytochemical and Pharmacological Studies on the Genus Psoralea: A Mini Review.

Authors:  Cong-Cong Li; Teng-Long Wang; Zhong-Qun Zhang; Wen-Qiang Yang; Yue-Fei Wang; Xin Chai; Chun-Hua Wang; Zheng Li
Journal:  Evid Based Complement Alternat Med       Date:  2016-11-17       Impact factor: 2.629

Review 7.  Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases.

Authors:  Yi-Ting Zhou; Lin Zhu; Yunyun Yuan; Shuang Ling; Jin-Wen Xu
Journal:  Oxid Med Cell Longev       Date:  2020-06-17       Impact factor: 6.543

8.  Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy.

Authors:  Qi Wu; Ai-Ling Tian; Sylvère Durand; Fanny Aprahamian; Nitharsshini Nirmalathasan; Wei Xie; Peng Liu; Liwei Zhao; Shuai Zhang; Hui Pan; Didac Carmona-Gutierrez; Frank Madeo; Yi Tu; Oliver Kepp; Guido Kroemer
Journal:  Cell Death Dis       Date:  2020-11-26       Impact factor: 8.469
  8 in total

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