Literature DB >> 19022674

Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

William Fenical1, Paul R Jensen, Michael A Palladino, Kin S Lam, G Kenneth Lloyd, Barbara C Potts.   

Abstract

The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential of the ocean to yield new natural products for drug discovery and development. Driving the success of this process was the linkage of academic research together with the ability and commitment of industry to undertake drug development and provide the resources and expertise to advance the entry of salinosporamide A (NPI-0052) into human clinical trials. This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19022674      PMCID： PMC2814440          DOI： 10.1016/j.bmc.2008.10.075

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  39 in total

Review 1.  Bioactive microbial metabolites.

Authors:  János Bérdy
Journal:  J Antibiot (Tokyo)       Date:  2005-01       Impact factor: 2.649

2.  Probing the specificity of the bovine pituitary multicatalytic proteinase complex by inhibitors, activators, and by chemical modification.

Authors:  S Wilk; M Pereira; B Yu
Journal:  Biomed Biochim Acta       Date:  1991

Review 3.  The ubiquitin system.

Authors:  A Hershko; A Ciechanover
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

4.  Studies on marine microorganisms. 3. Transport of spores of actinomycete into shallow sea mud and the effect of salt and temperature on their survival.

Authors:  Y Okami; T Okazaki
Journal:  J Antibiot (Tokyo)       Date:  1974-04       Impact factor: 2.649

5.  Actinomycetes in North Sea and Atlantic Ocean sediments.

Authors:  H Weyland
Journal:  Nature       Date:  1969-08-23       Impact factor: 49.962

6.  Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Authors:  Michael Groll; Robert Huber; Barbara C M Potts
Journal:  J Am Chem Soc       Date:  2006-04-19       Impact factor: 15.419

7.  Total synthesis of salinosporamide A.

Authors:  Atsushi Endo; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2005-06-15       Impact factor: 15.419

8.  Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor.

Authors:  Venkat R Macherla; Scott S Mitchell; Rama Rao Manam; Katherine A Reed; Ta-Hsiang Chao; Benjamin Nicholson; Gordafaried Deyanat-Yazdi; Bao Mai; Paul R Jensen; William F Fenical; Saskia T C Neuteboom; Kin S Lam; Michael A Palladino; Barbara C M Potts
Journal:  J Med Chem       Date:  2005-06-02       Impact factor: 7.446

9.  Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin.

Authors:  G Fenteany; R F Standaert; W S Lane; S Choi; E J Corey; S L Schreiber
Journal:  Science       Date:  1995-05-05       Impact factor: 47.728

10.  Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia.

Authors:  Aldo M Roccaro; Xavier Leleu; Antonio Sacco; Xiaoying Jia; Molly Melhem; Anne-Sophie Moreau; Hai T Ngo; Judith Runnels; Abdelkareem Azab; Feda Azab; Nicholas Burwick; Mena Farag; Steven P Treon; Michael A Palladino; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson; Irene M Ghobrial
Journal:  Blood       Date:  2008-03-03       Impact factor: 22.113
View more
  76 in total

Review 1.  Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.

Authors:  Tobias A M Gulder; Bradley S Moore
Journal:  Angew Chem Int Ed Engl       Date:  2010-12-03       Impact factor: 15.336

2.  Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.

Authors:  Anna Lechner; Alessandra S Eustáquio; Tobias A M Gulder; Mathias Hafner; Bradley S Moore
Journal:  Chem Biol       Date:  2011-12-23

3.  Unique actinomycetes from marine caves and coral reef sediments provide novel PKS and NRPS biosynthetic gene clusters.

Authors:  Tyler W Hodges; Marc Slattery; Julie B Olson
Journal:  Mar Biotechnol (NY)       Date:  2011-10-15       Impact factor: 3.619

4.  The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution.

Authors:  Alessandra S Eustáquio; Sang-Jip Nam; Kevin Penn; Anna Lechner; Micheal C Wilson; William Fenical; Paul R Jensen; Bradley S Moore
Journal:  Chembiochem       Date:  2011-01-03       Impact factor: 3.164

Review 5.  Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants.

Authors:  Ocky K Radjasa; Yvette M Vaske; Gabriel Navarro; Hélène C Vervoort; Karen Tenney; Roger G Linington; Phillip Crews
Journal:  Bioorg Med Chem       Date:  2011-07-26       Impact factor: 3.641

Review 6.  Taxonomy, Physiology, and Natural Products of Actinobacteria.

Authors:  Essaid Ait Barka; Parul Vatsa; Lisa Sanchez; Nathalie Gaveau-Vaillant; Cedric Jacquard; Jan P Meier-Kolthoff; Hans-Peter Klenk; Christophe Clément; Yder Ouhdouch; Gilles P van Wezel
Journal:  Microbiol Mol Biol Rev       Date:  2015-11-25       Impact factor: 11.056

7.  α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.

Authors:  Martina Bazzaro; Ravi K Anchoori; Mohana Krishna R Mudiam; Olga Issaenko; Srinivas Kumar; Balasubramanyam Karanam; Zhenhua Lin; Rachel Isaksson Vogel; Riccardo Gavioli; Federica Destro; Valeria Ferretti; Richard B S Roden; Saeed R Khan
Journal:  J Med Chem       Date:  2010-12-27       Impact factor: 7.446

8.  Nitropyrrolins A-E, cytotoxic farnesyl-α-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae.

Authors:  Hak Cheol Kwon; Ana Paula D M Espindola; Jin-Soo Park; Alejandra Prieto-Davó; Mickea Rose; Paul R Jensen; William Fenical
Journal:  J Nat Prod       Date:  2010-11-23       Impact factor: 4.050

9.  Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations.

Authors:  Henry Nguyen; Gil Ma; Tatiana Gladysheva; Trisha Fremgen; Daniel Romo
Journal:  J Org Chem       Date:  2010-11-03       Impact factor: 4.354

10.  Marine natural products: a new wave of drugs?

Authors:  Rana Montaser; Hendrik Luesch
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.