| Literature DB >> 19022669 |
Nian Zhou1, Wayne Zeller, Michael Krohn, Herb Anderson, Jun Zhang, Emmanuel Onua, Alex S Kiselyov, Jose Ramirez, Gułrún Halldorsdottir, Thornorkell Andrésson, Mark E Gurney, Jasbir Singh.
Abstract
A series of potent and selective EP(3) receptor antagonists are described. Utilizing a pharmacophore model developed for the EP(3) receptor, a series of 3,4-disubstituted indoles were shown to be high affinity ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors and are potent antagonists in functional assays.Entities:
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Year: 2008 PMID： 19022669 DOI： 10.1016/j.bmcl.2008.11.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823