Literature DB >> 19022324

Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates.

J K Simon1, R Wahid, M Maciel, W L Picking, K L Kotloff, M M Levine, M B Sztein.   

Abstract

We evaluated B memory responses in healthy adult volunteers who received one oral dose of live-attenuated Shigella flexneri 2a vaccine. LPS-specific B(M) cells increased from a median of 0 at baseline to 20 spot forming cells (SFC)/10(6) expanded cells following vaccination (p=0.008). A strong correlation was found between post-vaccination anti-LPS B(M) cell counts and peak serum anti-LPS IgG titers (rs=0.95, p=0.0003). Increases in B(M) specific for IpaB approaching significance were also observed. In sum, oral vaccination with live-attenuated S. flexneri 2a elicits B(M) cells to LPS and IpaB, suggesting that B(M) responses to Shigella antigens should be further studied as a suitable surrogate of protection in shigellosis.

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Year:  2008        PMID： 19022324      PMCID： PMC3753173          DOI： 10.1016/j.vaccine.2008.10.081

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  31 in total

1.  Correlation analysis between frequencies of circulating antigen-specific IgG-bearing memory B cells and serum titers of antigen-specific IgG.

Authors:  H Leyendeckers; M Odendahl; A Löhndorf; J Irsch; M Spangfort; S Miltenyi; N Hunzelmann; M Assenmacher; A Radbruch; J Schmitz
Journal:  Eur J Immunol       Date:  1999-04       Impact factor: 5.532

Review 2.  B-cell memory: are subsets necessary?

Authors:  David Tarlinton
Journal:  Nat Rev Immunol       Date:  2006-10       Impact factor: 53.106

Review 3.  Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road.

Authors:  Myron M Levine; Karen L Kotloff; Eileen M Barry; Marcela F Pasetti; Marcelo B Sztein
Journal:  Nat Rev Microbiol       Date:  2007-07       Impact factor: 60.633

4.  Evaluation of circulating intestinally committed memory B cells in children vaccinated with attenuated human rotavirus vaccine.

Authors:  Olga Lucía Rojas; Liliana Caicedo; Carolina Guzmán; Luz-Stella Rodríguez; Javier Castañeda; Liliana Uribe; Yohanna Andrade; Ricardo Pinzón; Carlos Fernando Narváez; Juan Manuel Lozano; Beatrice De Vos; Manuel A Franco; Juana Angel
Journal:  Viral Immunol       Date:  2007       Impact factor: 2.257

5.  The kinetics and phenotype of the human B-cell response following immunization with a heptavalent pneumococcal-CRM conjugate vaccine.

Authors:  Elizabeth A Clutterbuck; Penny Salt; Sarah Oh; Arnaud Marchant; Peter Beverley; Andrew John Pollard
Journal:  Immunology       Date:  2006-11       Impact factor: 7.397

6.  Detection of memory B lymphocytes specific to hepatitis B virus (HBV) surface antigen (HBsAg) from HBsAg-vaccinated or HBV-immunized subjects by ELISPOT assay.

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Journal:  J Immunol Methods       Date:  2006-08-18       Impact factor: 2.303

7.  CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells.

Authors:  Dominic F Kelly; Mathew D Snape; Elizabeth A Clutterbuck; Elizabeth A Cutterbuck; Sarah Green; Claire Snowden; Linda Diggle; Ly-mee Yu; Astrid Borkowski; E Richard Moxon; Andrew J Pollard
Journal:  Blood       Date:  2006-05-04       Impact factor: 22.113

8.  Global burden of Shigella infections: implications for vaccine development and implementation of control strategies.

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9.  Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri.

Authors:  Susan E Birket; Amanda T Harrington; Marianela Espina; Nathan D Smith; Christina M Terry; Numukunda Darboe; Aaron P Markham; C Russell Middaugh; Wendy L Picking; William D Picking
Journal:  Biochemistry       Date:  2007-06-16       Impact factor: 3.162

Review 10.  Understanding and making use of human memory B cells.

Authors:  Antonio Lanzavecchia; Nadia Bernasconi; Elisabetta Traggiai; Claudia R Ruprecht; Davide Corti; Federica Sallusto
Journal:  Immunol Rev       Date:  2006-06       Impact factor: 12.988
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  22 in total

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Authors:  Marcela F Pasetti; Myron M Levine
Journal:  Clin Vaccine Immunol       Date:  2012-09-19

Review 2.  Progress and pitfalls in Shigella vaccine research.

Authors:  Eileen M Barry; Marcela F Pasetti; Marcelo B Sztein; Alessio Fasano; Karen L Kotloff; Myron M Levine
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2013-02-19       Impact factor: 46.802

3.  Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory.

Authors:  Thorsten Demberg; Amelia C Ettinger; Stanley Aladi; Katherine McKinnon; Thea Kuddo; David Venzon; L Jean Patterson; Terry M Phillips; Marjorie Robert-Guroff
Journal:  Vaccine       Date:  2011-06-25       Impact factor: 3.641

Review 4.  Immunology of gut mucosal vaccines.

Authors:  Marcela F Pasetti; Jakub K Simon; Marcelo B Sztein; Myron M Levine
Journal:  Immunol Rev       Date:  2011-01       Impact factor: 12.988

5.  Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+IgD-S. Typhi-specific IgA and IgG B memory cells in humans.

Authors:  Rezwanul Wahid; Marcela F Pasetti; Milton Maciel; Jakub K Simon; Carol O Tacket; Myron M Levine; Marcelo B Sztein
Journal:  Clin Immunol       Date:  2010-12-10       Impact factor: 3.969

6.  Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates.

Authors:  J K Simon; M Maciel; E D Weld; R Wahid; M F Pasetti; W L Picking; K L Kotloff; M M Levine; M B Sztein
Journal:  Clin Immunol       Date:  2011-03-08       Impact factor: 3.969

7.  Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans.

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8.  Circulating Gut-Homing (α4β7+) Plasmablast Responses against Shigella Surface Protein Antigens among Hospitalized Patients with Diarrhea.

Authors:  Anuradha Sinha; Ayan Dey; Giulietta Saletti; Pradip Samanta; Partha Sarathi Chakraborty; M K Bhattacharya; Santanu Ghosh; T Ramamurthy; Jae-Ouk Kim; Jae Seung Yang; Dong Wook Kim; Cecil Czerkinsky; Ranjan K Nandy
Journal:  Clin Vaccine Immunol       Date:  2016-07-05

9.  Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a.

Authors:  Rezwanul Wahid; Jakub K Simon; Wendy L Picking; Karen L Kotloff; Myron M Levine; Marcelo B Sztein
Journal:  Clin Immunol       Date:  2013-03-26       Impact factor: 3.969

10.  A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization.

Authors:  David I Bernstein; Marcela F Pasetti; Rebecca Brady; Amanda D Buskirk; Rezwanul Wahid; Michelle Dickey; Mitchell Cohen; Holly Baughman; Jill El-Khorazaty; Nicole Maier; Marcelo B Sztein; Shahida Baqar; A Louis Bourgeois
Journal:  Vaccine       Date:  2018-12-15       Impact factor: 3.641
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