OBJECTIVE: Our purpose was to study the association between familial and particularly fetal tobacco smoke exposure and vascular damage in young adulthood. METHODS AND RESULTS: From a cohort of 732 young adults, birth data were collected and in young adulthood ultrasound measurement of common carotid artery intima-media thickness (CIMT) was performed. Data on parental smoking were obtained by standardized questionnaires. Twenty-nine percent of the mothers smoked during pregnancy. Offspring of mothers who smoked had 13.4 microm thicker CIMT (95% CI: 5.5, 21.3; P=0.001) than offspring of mothers who did not smoke in pregnancy. Adjustment for known CIMT risk factors (participant's age, gender, BMI, pulse pressure, and LDL-cholesterol) yielded no change (9.4 microm, 95% CI: 1.9, 16.3, P=0.01) nor did adjustment for current smoking of parents (10.6 microm, 95% CI: 0.4 to 20.8, P=0.04), for participants' current smoking and pack-years (11.5 microm, 95% CI: 3.5 to 19.4, P=0.004) or for parental socioeconomic status (SES; 13.0 microm, 95% CI: 5.0, 21.1, P=0.002). Thicker CIMT was associated with exclusive paternal smoking in pregnancy, somewhat stronger with exclusive maternal smoking and strongest with both parents smoking (P (linear trend)=0.001). Offspring of particularly mothers who smoked an above median number of cigarettes in pregnancy had thicker CIMT than those smoking less than median or no cigarettes (P (linear trend) <0.0001). CONCLUSIONS: Permanent vascular damage is partly attributable to familial tobacco smoke exposure, an association that might be initiated in gestation.
OBJECTIVE: Our purpose was to study the association between familial and particularly fetal tobacco smoke exposure and vascular damage in young adulthood. METHODS AND RESULTS: From a cohort of 732 young adults, birth data were collected and in young adulthood ultrasound measurement of common carotid artery intima-media thickness (CIMT) was performed. Data on parental smoking were obtained by standardized questionnaires. Twenty-nine percent of the mothers smoked during pregnancy. Offspring of mothers who smoked had 13.4 microm thicker CIMT (95% CI: 5.5, 21.3; P=0.001) than offspring of mothers who did not smoke in pregnancy. Adjustment for known CIMT risk factors (participant's age, gender, BMI, pulse pressure, and LDL-cholesterol) yielded no change (9.4 microm, 95% CI: 1.9, 16.3, P=0.01) nor did adjustment for current smoking of parents (10.6 microm, 95% CI: 0.4 to 20.8, P=0.04), for participants' current smoking and pack-years (11.5 microm, 95% CI: 3.5 to 19.4, P=0.004) or for parental socioeconomic status (SES; 13.0 microm, 95% CI: 5.0, 21.1, P=0.002). Thicker CIMT was associated with exclusive paternal smoking in pregnancy, somewhat stronger with exclusive maternal smoking and strongest with both parents smoking (P (linear trend)=0.001). Offspring of particularly mothers who smoked an above median number of cigarettes in pregnancy had thicker CIMT than those smoking less than median or no cigarettes (P (linear trend) <0.0001). CONCLUSIONS: Permanent vascular damage is partly attributable to familial tobacco smoke exposure, an association that might be initiated in gestation.
Authors: Andrea L Knecht; Lisa Truong; Skylar W Marvel; David M Reif; Abraham Garcia; Catherine Lu; Michael T Simonich; Justin G Teeguarden; Robert L Tanguay Journal: Toxicol Appl Pharmacol Date: 2017-06-03 Impact factor: 4.219
Authors: Shalini Dixit; Mark J Pletcher; Eric Vittinghoff; Kourtney Imburgia; Carol Maguire; Isaac R Whitman; Stanton A Glantz; Jeffrey E Olgin; Gregory M Marcus Journal: Heart Rhythm Date: 2015-09-01 Impact factor: 6.343
Authors: Lea A Cupul-Uicab; Rolv Skjaerven; Kjell Haug; Gregory S Travlos; Ralph E Wilson; Merete Eggesbø; Jane A Hoppin; Kristina W Whitworth; Matthew P Longnecker Journal: Environ Health Perspect Date: 2012-07-19 Impact factor: 9.031