| Literature DB >> 19020108 |
María R López-Alvarez1, María V Martínez-Sánchez, María G Salgado-Cecilia, José A Campillo, Damian Heine-Suñer, Florentina Villar-Permuy, José L Fuster, Agueda Bas, Juana Gil-Herrera, Manuel Muro, Ana M García-Alonso, María R Alvarez-López, Alfredo Minguela.
Abstract
We report the first case of hemophagocytic lymphohistiocytosis (HLH) induced by the monoclonal expansion of Epstein-Barr virus (EBV)-negative NK cells. Consanguinity of the patient's parents made it necessary to discard familial HLH in the patient and her sister with identical HLA markers and demonstrate that no cause other than the expansion of NK cells, which secrete high levels of gamma interferon, was inducing HLH in this patient.Entities:
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Year: 2008 PMID: 19020108 PMCID: PMC2620662 DOI: 10.1128/CVI.00358-08
Source DB: PubMed Journal: Clin Vaccine Immunol ISSN: 1556-679X