Literature DB >> 19020108

Association of monoclonal expansion of Epstein-Barr virus-negative CD158a+ NK cells secreting large amounts of gamma interferon with hemophagocytic lymphohistiocytosis.

María R López-Alvarez1, María V Martínez-Sánchez, María G Salgado-Cecilia, José A Campillo, Damian Heine-Suñer, Florentina Villar-Permuy, José L Fuster, Agueda Bas, Juana Gil-Herrera, Manuel Muro, Ana M García-Alonso, María R Alvarez-López, Alfredo Minguela.   

Abstract

We report the first case of hemophagocytic lymphohistiocytosis (HLH) induced by the monoclonal expansion of Epstein-Barr virus (EBV)-negative NK cells. Consanguinity of the patient's parents made it necessary to discard familial HLH in the patient and her sister with identical HLA markers and demonstrate that no cause other than the expansion of NK cells, which secrete high levels of gamma interferon, was inducing HLH in this patient.

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Year:  2008        PMID: 19020108      PMCID: PMC2620662          DOI: 10.1128/CVI.00358-08

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN: 1556-679X


  11 in total

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2.  Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A.

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Journal:  Hum Mutat       Date:  2006-01       Impact factor: 4.878

Review 3.  Advances in the management of hemophagocytic lymphohistiocytosis.

Authors:  S Imashuku
Journal:  Int J Hematol       Date:  2000-07       Impact factor: 2.490

Review 4.  Epstein-Barr virus-infected natural killer cell leukemia.

Authors:  K Akashi; S Mizuno
Journal:  Leuk Lymphoma       Date:  2000-12

5.  Detection and typing of lymphotropic herpesviruses by multiplex polymerase chain reaction.

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Journal:  J Virol Methods       Date:  1999-04       Impact factor: 2.014

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7.  Simultaneous detection of measles virus, rubella virus, and parvovirus B19 by using multiplex PCR.

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Review 8.  Perforin and lymphohistiocytic proliferative disorders.

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9.  Fragile-X syndrome and skewed X-chromosome inactivation within a family: a female member with complete inactivation of the functional X chromosome.

Authors:  D Heine-Suñer; L Torres-Juan; M Morlà; X Busquets; F Barceló; G Picó; L Bonilla; N Govea; M Bernués; J Rosell
Journal:  Am J Med Genet A       Date:  2003-10-01       Impact factor: 2.802

10.  Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

Authors:  Jérôme Feldmann; Isabelle Callebaut; Graça Raposo; Stéphanie Certain; Delphine Bacq; Cécile Dumont; Nathalie Lambert; Marie Ouachée-Chardin; Gaëlle Chedeville; Hannah Tamary; Véronique Minard-Colin; Etienne Vilmer; Stéphane Blanche; Françoise Le Deist; Alain Fischer; Geneviève de Saint Basile
Journal:  Cell       Date:  2003-11-14       Impact factor: 41.582

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  2 in total

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Authors:  Eric J Vick; Kruti Patel; Philippe Prouet; Mike G Martin
Journal:  Blood Adv       Date:  2017-05-09

2.  Overexpression of KIR inhibitory ligands (HLA-I) determines that immunosurveillance of myeloma depends on diverse and strong NK cell licensing.

Authors:  María V Martínez-Sánchez; Adela Periago; Isabel Legaz; Lourdes Gimeno; Anna Mrowiec; Natividad R Montes-Barqueros; José A Campillo; José M Bolarin; María V Bernardo; María R López-Álvarez; Consuelo González; María C García-Garay; Manuel Muro; Valentin Cabañas-Perianes; Jose L Fuster; Ana M García-Alonso; José M Moraleda; María R Álvarez-Lopez; Alfredo Minguela
Journal:  Oncoimmunology       Date:  2015-10-29       Impact factor: 8.110

  2 in total

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