OBJECTIVES: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS). METHODS: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the chi(2) test. RESULTS: KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls. CONCLUSIONS: Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.
OBJECTIVES: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS). METHODS: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the chi(2) test. RESULTS:KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls. CONCLUSIONS: Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.
Authors: B Erer; M Takeuchi; D Ustek; I Tugal-Tutkun; E Seyahi; Y Özyazgan; J Duymaz-Tozkir; A Gül; D L Kastner; E F Remmers; M J Ombrello Journal: Genes Immun Date: 2016-10-06 Impact factor: 2.676
Authors: Ivan V Zvyagin; Ilgar Z Mamedov; Olga V Britanova; Dmitriy B Staroverov; Evgeni L Nasonov; Anna G Bochkova; Anna V Chkalina; Alexei A Kotlobay; Dmitriy O Korostin; Denis V Rebrikov; Sergey Lukyanov; Yuri B Lebedev; Dmitriy M Chudakov Journal: Cell Mol Immunol Date: 2010-09-06 Impact factor: 11.530
Authors: Ralph D Levinson; Tammy M Martin; Lihui Luo; Elham Ashouri; James T Rosenbaum; Justine R Smith; Carrie R Austin; Joseph R Lutt; Raja Rajalingam Journal: Invest Ophthalmol Vis Sci Date: 2009-10-22 Impact factor: 4.799
Authors: María V Martínez-Sánchez; Adela Periago; Isabel Legaz; Lourdes Gimeno; Anna Mrowiec; Natividad R Montes-Barqueros; José A Campillo; José M Bolarin; María V Bernardo; María R López-Álvarez; Consuelo González; María C García-Garay; Manuel Muro; Valentin Cabañas-Perianes; Jose L Fuster; Ana M García-Alonso; José M Moraleda; María R Álvarez-Lopez; Alfredo Minguela Journal: Oncoimmunology Date: 2015-10-29 Impact factor: 8.110