| Literature DB >> 19019676 |
Heather A Barnett1, Diane M Coe, Tony W J Cooper, Torquil I Jack, Haydn T Jones, Simon J F Macdonald, Iain M McLay, Natalie Rayner, Rosemary Z Sasse, Tracy J Shipley, Phil A Skone, Graham I Somers, Simon Taylor, Iain J Uings, James M Woolven, Gordon G Weingarten.
Abstract
Aryl aminopyrazole amides capped with N-alkylbenzamides 13-16 are selective glucocorticoid receptor agonists. 2,6-Disubstituted benzamides have prednisolone-like potency or better in vitro. Good oral exposure was demonstrated in the rat, with compounds with lower lipophilicity, for example N-hydroxyethyl benzamides (e.g., 16e).Entities:
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Year: 2008 PMID： 19019676 DOI： 10.1016/j.bmcl.2008.10.128
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823