| Literature DB >> 19019403 |
Vladimir N Loparev1, Elena N Rubtcova, Vanda Bostik, Valentina Tzaneva, Andreas Sauerbrei, Alma Robo, Eva Sattler-Dornbacher, Iva Hanovcova, Vera Stepanova, Miroslav Splino, Vladimir Eremin, Marjaleena Koskiniemi, Olga E Vankova, D Scott Schmid.
Abstract
Phylogenetic analysis of 19 complete VZV genomic sequences resolves wild-type strains into 5 genotypes (E1, E2, J, M1, and M2). Complete sequences for M3 and M4 strains are unavailable, but targeted analyses of representative strains suggest they are stable, circulating VZV genotypes. Sequence analysis of VZV isolates identified both shared and specific markers for every genotype and validated a unified VZV genotyping strategy. Despite high genotype diversity no evidence for intra-genotypic recombination was observed. Five of seven VZV genotypes were reliably discriminated using only four single nucleotide polymorphisms (SNP) present in ORF22, and the E1 and E2 genotypes were resolved using SNP located in ORF21, ORF22 or ORF50. Sequence analysis of 342 clinical varicella and zoster specimens from 18 European countries identified the following distribution of VZV genotypes: E1, 221 (65%); E2, 87 (25%); M1, 20 (6%); M2, 3 (1%); M4, 11 (3%). No M3 or J strains were observed.Entities:
Mesh：
Year: 2008 PMID： 19019403 DOI： 10.1016/j.virol.2008.10.026
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616