BACKGROUND: Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted to describe the prevalence of insulin resistance among HIV-infected children receiving HAART. METHODS: Insulin resistance was assessed at 96 weeks of treatment with nonnucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (nevirapine or efavirenz with stavudine and lamivudine) among children in Chiang Mai, Thailand. Insulin resistance was defined as homeostasis model assessment for insulin resistance (HOMA-IR) >/=3.16, fasting c-peptide >/=4.40 ng/mL or fasting insulin >/=25.0 muU/mL. Impaired fasting glucose (IFG) was defined as glucose >/=110 mg/dL. Measurements were analysed for associations with age, lipodystrophy, treatment regimen and clinical data. RESULTS: The prevalence of insulin resistance was 6.5%; no child had IFG. Those with insulin resistance were older with higher body mass index. Children >/=10 years had higher HOMA-IR, c-peptide and insulin, but no difference was seen in the frequency of insulin resistance. No associations between insulin resistance and lipodystrophy or treatment regimen were detected. CONCLUSIONS: Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy.
BACKGROUND: Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted to describe the prevalence of insulin resistance among HIV-infectedchildren receiving HAART. METHODS:Insulin resistance was assessed at 96 weeks of treatment with nonnucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (nevirapine or efavirenz with stavudine and lamivudine) among children in Chiang Mai, Thailand. Insulin resistance was defined as homeostasis model assessment for insulin resistance (HOMA-IR) >/=3.16, fasting c-peptide >/=4.40 ng/mL or fasting insulin >/=25.0 muU/mL. Impaired fasting glucose (IFG) was defined as glucose >/=110 mg/dL. Measurements were analysed for associations with age, lipodystrophy, treatment regimen and clinical data. RESULTS: The prevalence of insulin resistance was 6.5%; no child had IFG. Those with insulin resistance were older with higher body mass index. Children >/=10 years had higher HOMA-IR, c-peptide and insulin, but no difference was seen in the frequency of insulin resistance. No associations between insulin resistance and lipodystrophy or treatment regimen were detected. CONCLUSIONS:Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy.
Authors: Mitchell E Geffner; Kunjal Patel; Tracie L Miller; Rohan Hazra; Margarita Silio; Russell B Van Dyke; William Borkowsky; Carol Worrell; Linda A DiMeglio; Denise L Jacobson Journal: Horm Res Paediatr Date: 2011-10-26 Impact factor: 2.852
Authors: Daniel Blázquez; José Tomás Ramos-Amador; Talía Saínz; María José Mellado; Marta García-Ascaso; María Isabel De José; Pablo Rojo; María Luisa Navarro; María Ángeles Muñoz-Fernández; Jesús Saavedra; Miguel Angel Roa; Santiago Jiménez; José Beceiro; Luis Prieto; Milagros García Hortelano; María Isabel González-Tomé Journal: BMC Infect Dis Date: 2015-03-08 Impact factor: 3.090
Authors: Olukemi O Ige; Christopher S Yilgwan; Augustine O Ebonyi; Ruth Adah; Idris Adedeji; Esther S Yiltok; Stephen Oguche; Fidelia Bode-Thomas Journal: J Virus Erad Date: 2017-07-01