OBJECTIVES: To compare the 6- and 12-month outcomes of patients who recovered from subsyndromal delirium (SSD) by 8 weeks with the outcomes of patients who did not recover or did not have an index episode. DESIGN: Secondary analysis of data collected for a cohort study of the prognosis of delirium. SETTING: University-affiliated primary acute care hospital. PARTICIPANTS: Older medical inpatients with prevalent, incident, or no SSD were classified into three mutually exclusive groups at 8 weeks (SSD-recovered, SSD-not recovered, no SSD) and followed up at 6 and 12 months. MEASUREMENTS: The primary hierarchical composite outcome was death, institutionalization, or cognitive or functional decline at 6 and 12 months. In secondary analyses, components of the primary outcome were examined separately. RESULTS: Of the 129 patients assessed at 8 weeks, 51, 47, and 31 met criteria for SSD-recovered, SSD-not recovered and no SSD, respectively. At 6 and 12 months, the primary and secondary outcomes of the SSD-recovered group were better than the outcomes of the SSD-not recovered group and, for the most part, intermediate between the outcomes of the SSD-not recovered and no SSD groups. CONCLUSION: Recovery from SSD appears to predict better longer-term outcomes than no recovery. Efforts to identify and treat SSD in older medical inpatients may improve outcomes.
OBJECTIVES: To compare the 6- and 12-month outcomes of patients who recovered from subsyndromal delirium (SSD) by 8 weeks with the outcomes of patients who did not recover or did not have an index episode. DESIGN: Secondary analysis of data collected for a cohort study of the prognosis of delirium. SETTING: University-affiliated primary acute care hospital. PARTICIPANTS: Older medical inpatients with prevalent, incident, or no SSD were classified into three mutually exclusive groups at 8 weeks (SSD-recovered, SSD-not recovered, no SSD) and followed up at 6 and 12 months. MEASUREMENTS: The primary hierarchical composite outcome was death, institutionalization, or cognitive or functional decline at 6 and 12 months. In secondary analyses, components of the primary outcome were examined separately. RESULTS: Of the 129 patients assessed at 8 weeks, 51, 47, and 31 met criteria for SSD-recovered, SSD-not recovered and no SSD, respectively. At 6 and 12 months, the primary and secondary outcomes of the SSD-recovered group were better than the outcomes of the SSD-not recovered group and, for the most part, intermediate between the outcomes of the SSD-not recovered and no SSD groups. CONCLUSION: Recovery from SSD appears to predict better longer-term outcomes than no recovery. Efforts to identify and treat SSD in older medical inpatients may improve outcomes.
Authors: Nathan E Brummel; Leanne M Boehm; Timothy D Girard; Pratik P Pandharipande; James C Jackson; Christopher G Hughes; Mayur B Patel; Jin H Han; Eduard E Vasilevskis; Jennifer L Thompson; Rameela Chandrasekhar; Gordon R Bernard; Robert S Dittus; E Wesley Ely Journal: Am J Crit Care Date: 2017-11 Impact factor: 2.228
Authors: Esteban Sepulveda; Maeve Leonard; Jose G Franco; Dimitrios Adamis; Geraldine McCarthy; Colum Dunne; Paula T Trzepacz; Ana M Gaviria; Joan de Pablo; Elisabet Vilella; David J Meagher Journal: Alzheimers Dement (Amst) Date: 2016-12-01
Authors: Jan N M Schieveld; Judith A van der Valk; Inge Smeets; Eline Berghmans; Renske Wassenberg; Piet L M N Leroy; Gijs D Vos; Jim van Os Journal: Intensive Care Med Date: 2009-11 Impact factor: 17.440