OBJECTIVES: To examine the association between serum parathyroid hormone (PTH) levels and incident falls in older adults with diabetes mellitus. DESIGN: Longitudinal analysis of incident falls over 1 year in a substudy of participants with diabetes mellitus in the Health, Aging and Body Composition Study. SETTING: Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Well-functioning, community-dwelling black and white adults aged 70 to 79 with diabetes mellitus (N=472). MEASUREMENTS: Measured baseline serum PTH. Self-report of falls over the subsequent 12 months. Baseline physical performance and self-reported demographic, behavioral, and health status measures including kidney function, chronic conditions, and medication use. RESULTS: One-third (30.3%) of participants reported falling over 1 year of follow-up. Mean baseline serum PTH was 53.5+/-30.0 pg/mL in nonfallers and 62.6+/-46.2 pg/mL in fallers (P=.01). For every 1 standard deviation (36 pg/mL) increment in baseline serum PTH, there was approximately a 30% greater likelihood of reporting a fall in the subsequent year, after adjusting for age, sex, race, field center, alcohol consumption, body mass index, physical activity, and winter or spring season (adjusted odds ratio (aOR)=1.30, 95% confidence interval (CI)=1.06-1.59). Further adjustment for kidney function, chronic conditions, medication and supplement use, and physical performance attenuated the association slightly (aOR=1.26, 95% CI=1.01-1.58). A trend remained after additional adjustment for reported falls in the previous year. CONCLUSION: Higher serum PTH was associated with incident falls in older, well-functioning men and women with diabetes mellitus. Further investigation aimed at understanding the underlying mechanism for the association between serum PTH and falls is needed.
OBJECTIVES: To examine the association between serum parathyroid hormone (PTH) levels and incident falls in older adults with diabetes mellitus. DESIGN: Longitudinal analysis of incident falls over 1 year in a substudy of participants with diabetes mellitus in the Health, Aging and Body Composition Study. SETTING: Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Well-functioning, community-dwelling black and white adults aged 70 to 79 with diabetes mellitus (N=472). MEASUREMENTS: Measured baseline serum PTH. Self-report of falls over the subsequent 12 months. Baseline physical performance and self-reported demographic, behavioral, and health status measures including kidney function, chronic conditions, and medication use. RESULTS: One-third (30.3%) of participants reported falling over 1 year of follow-up. Mean baseline serum PTH was 53.5+/-30.0 pg/mL in nonfallers and 62.6+/-46.2 pg/mL in fallers (P=.01). For every 1 standard deviation (36 pg/mL) increment in baseline serum PTH, there was approximately a 30% greater likelihood of reporting a fall in the subsequent year, after adjusting for age, sex, race, field center, alcohol consumption, body mass index, physical activity, and winter or spring season (adjusted odds ratio (aOR)=1.30, 95% confidence interval (CI)=1.06-1.59). Further adjustment for kidney function, chronic conditions, medication and supplement use, and physical performance attenuated the association slightly (aOR=1.26, 95% CI=1.01-1.58). A trend remained after additional adjustment for reported falls in the previous year. CONCLUSION: Higher serum PTH was associated with incident falls in older, well-functioning men and women with diabetes mellitus. Further investigation aimed at understanding the underlying mechanism for the association between serum PTH and falls is needed.
Authors: G E Fuleihan; C M Gundberg; R Gleason; E M Brown; M E Stromski; F D Grant; P R Conlin Journal: J Clin Endocrinol Metab Date: 1994-12 Impact factor: 5.958
Authors: M Kleerekoper; D A Nelson; E L Peterson; M J Flynn; A S Pawluszka; G Jacobsen; P Wilson Journal: J Bone Miner Res Date: 1994-08 Impact factor: 6.741
Authors: F Cosman; D C Morgan; J W Nieves; V Shen; M M Luckey; D W Dempster; R Lindsay; M Parisien Journal: J Bone Miner Res Date: 1997-06 Impact factor: 6.741
Authors: Leon Flicker; Kate Mead; Robert J MacInnis; Caryl Nowson; Sam Scherer; Mark S Stein; Jennifer Thomasx; John L Hopper; John D Wark Journal: J Am Geriatr Soc Date: 2003-11 Impact factor: 5.562
Authors: P N Sambrook; J S Chen; L M March; I D Cameron; R G Cumming; S R Lord; J Zochling; Y Y Sitoh; T C Lau; J Schwarz; M J Seibel Journal: J Clin Endocrinol Metab Date: 2004-04 Impact factor: 5.958