| Literature DB >> 19016476 |
Arpana Agrawal1, Leah Wetherill, Danielle M Dick, Xiaoling Xuei, Anthony Hinrichs, Victor Hesselbrock, John Kramer, John I Nurnberger, Marc Schuckit, Laura J Bierut, Howard J Edenberg, Tatiana Foroud.
Abstract
Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Delta9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P = 0.05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence. 2008 Wiley-Liss, Inc.Entities:
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Year: 2009 PMID： 19016476 PMCID： PMC2703788 DOI： 10.1002/ajmg.b.30881
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568