Literature DB >> 1901640

Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva.

P G Toye1, B M Goddeeris, K Iams, A J Musoke, W I Morrison.   

Abstract

This study examines several aspects of a polymorphic, immunodominant molecule (PIM) found in the protozoan parasite, Theileria parva. The antigen is present in all T.p. parva stocks examined, and in the related subspecies, T.p.bovis and T.p.lawrencei. It is the predominant antigen recognized by antisera from immune cattle on Western blot analysis of schizont-infected lymphocytes, and is the only antigen which has been shown to react with anti-schizont monoclonal antibodies (MoAbs) on Western blots or in immunoprecipitations. The antigen shows polymorphism in both size and expression of antibody epitopes among the different stocks of T. parva. The antigen is present in sporozoites as well as schizonts.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1901640     DOI： 10.1111/j.1365-3024.1991.tb00262.x

Source DB:  PubMed          Journal:  Parasite Immunol        ISSN： 0141-9838            Impact factor:   2.280


  15 in total

1.  Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles.

Authors:  V Nene; A Musoke; E Gobright; S Morzaria
Journal:  Infect Immun       Date:  1996-06       Impact factor: 3.441

2.  Molecular genetic characterization and subcellular localization of a putative Theileria annulata membrane protein.

Authors:  Ilka Schneider; Daniel Haller; Ulrike Seitzer; Doreen Beyer; Jabbar S Ahmed
Journal:  Parasitol Res       Date:  2004-10-14       Impact factor: 2.289

3.  Characterisation of gp34, a GPI-anchored protein expressed by schizonts of Theileria parva and T. annulata.

Authors:  Gondga Xue; Conrad von Schubert; Pascal Hermann; Martina Peyer; Regina Maushagen; Jacqueline Schmuckli-Maurer; Peter Bütikofer; Gordon Langsley; Dirk A E Dobbelaere
Journal:  Mol Biochem Parasitol       Date:  2010-04-08       Impact factor: 1.759

4.  Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes.

Authors:  Philip Toye; Antony Musoke; Jan Naessens
Journal:  Infect Immun       Date:  2014-02-18       Impact factor: 3.441

5.  Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva.

Authors:  E L Taracha; B M Goddeeris; S P Morzaria; W I Morrison
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

6.  Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes.

Authors:  Simon P Graham; Roger Pellé; Yoshikazu Honda; Duncan M Mwangi; Nyerhovwo J Tonukari; Mat Yamage; E Jane Glew; Etienne P de Villiers; Trushar Shah; Richard Bishop; Evelyne Abuya; Elias Awino; James Gachanja; Anthony E Luyai; Ferdinand Mbwika; Anthony M Muthiani; David M Ndegwa; Moses Njahira; John K Nyanjui; Fredrick O Onono; Julius Osaso; Rosemary M Saya; Claude Wildmann; Claire M Fraser; Ian Maudlin; Malcolm J Gardner; Subhash P Morzaria; Sheena Loosmore; Sarah C Gilbert; Jean-Christophe Audonnet; Pierre van der Bruggen; Vishvanath Nene; Evans L N Taracha
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-21       Impact factor: 11.205

7.  Influence of host immunity on parasite diversity in Theileria parva.

Authors:  Frank Katzer; Daniel Ngugi; Christian Schnier; Alan R Walker; Declan J McKeever
Journal:  Infect Immun       Date:  2007-07-16       Impact factor: 3.441

8.  Humoral immune responses to Theileria parva in cattle as measured by two-dimensional western blotting.

Authors:  M Kishima; T T Dolan; R E Njamunggeh; C G Nkonge; P R Spooner
Journal:  Parasitol Res       Date:  1995       Impact factor: 2.289

9.  Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva.

Authors:  P Toye; J Nyanjui; B Goddeeris; A J Musoke
Journal:  Infect Immun       Date:  1996-05       Impact factor: 3.441

10.  Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage.

Authors:  Richard Bishop; Trushar Shah; Roger Pelle; David Hoyle; Terry Pearson; Lee Haines; Andrew Brass; Helen Hulme; Simon P Graham; Evans L N Taracha; Simon Kanga; Charles Lu; Brian Hass; Jennifer Wortman; Owen White; Malcolm J Gardner; Vishvanath Nene; Etienne P de Villiers
Journal:  Nucleic Acids Res       Date:  2005-09-25       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.