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Literature DB >> 19015525

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.

Elena P Sablin¹, April Woods, Irina N Krylova, Peter Hwang, Holly A Ingraham, Robert J Fletterick.

Abstract

The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 19015525 PMCID： PMC2587556 DOI： 10.1073/pnas.0808936105

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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