BACKGROUND: We investigated the clinicopathological features and evaluated the prognostic impact of age and sex on patients with gastric cancer. DESIGN: Retrospective study from 1993 to 2000. SETTING: Korea University Medical Center. PATIENTS: A total of 1299 patients with gastric cancer were divided into young (n = 175 [13.5%]) and older (n = 1124 [86.5%]) groups with an age cutoff of 40 years. MAIN OUTCOME MEASURES: Clinicopathological characteristics were investigated and survival analysis was performed according to sex for each age group. RESULTS: Tumor differentiation was significantly different between the 2 age groups. Among male patients, the young group had more undifferentiated tumors than the older group (P < .001) but, in female patients, both differentiation (P < .001) and operative methods (P = .008) were significantly different between the young and older groups. In male patients, the 10-year survival rate of the young group was higher (62.5%) than that of the older group (44.6%) (P = .03). Although it was not statistically significant, the survival rate of the older female group was higher than that of the young group (56.2% vs 51.9%). On multivariate analysis, tumor stage (P < .001) and sex (P = .042) were proved to be independent prognostic factors. CONCLUSIONS: Only tumor differentiation was an important difference between the 2 age groups, and prognosis was not affected by age. However, when sex was added to age as a factor, the older male and young female groups had an unfavorable prognosis. Therefore, we propose that sex hormones such as estrogens contribute to the survival differences, and further studies are needed to confirm this possibility.
BACKGROUND: We investigated the clinicopathological features and evaluated the prognostic impact of age and sex on patients with gastric cancer. DESIGN: Retrospective study from 1993 to 2000. SETTING: Korea University Medical Center. PATIENTS: A total of 1299 patients with gastric cancer were divided into young (n = 175 [13.5%]) and older (n = 1124 [86.5%]) groups with an age cutoff of 40 years. MAIN OUTCOME MEASURES: Clinicopathological characteristics were investigated and survival analysis was performed according to sex for each age group. RESULTS:Tumor differentiation was significantly different between the 2 age groups. Among male patients, the young group had more undifferentiated tumors than the older group (P < .001) but, in female patients, both differentiation (P < .001) and operative methods (P = .008) were significantly different between the young and older groups. In male patients, the 10-year survival rate of the young group was higher (62.5%) than that of the older group (44.6%) (P = .03). Although it was not statistically significant, the survival rate of the older female group was higher than that of the young group (56.2% vs 51.9%). On multivariate analysis, tumor stage (P < .001) and sex (P = .042) were proved to be independent prognostic factors. CONCLUSIONS: Only tumor differentiation was an important difference between the 2 age groups, and prognosis was not affected by age. However, when sex was added to age as a factor, the older male and young female groups had an unfavorable prognosis. Therefore, we propose that sex hormones such as estrogens contribute to the survival differences, and further studies are needed to confirm this possibility.
Authors: Hee Man Kim; Kyung Ho Pak; Moon Jae Chung; Jae Hee Cho; Woo Jin Hyung; Sung Hoon Noh; Choong Bai Kim; Yong Chan Lee; Si Young Song; Sang Kil Lee Journal: Surg Endosc Date: 2011-04-13 Impact factor: 4.584
Authors: Soo-Jeong Cho; Il Ju Choi; Chan Gyoo Kim; Jong Yeul Lee; Myeong-Cherl Kook; Moon-Woo Seong; Sook Ryun Park; Jong Seok Lee; Young-Woo Kim; Keun Won Ryu; Jun Ho Lee; Byung-Ho Nam; Young-Iee Park Journal: Gut Liver Date: 2010-12-17 Impact factor: 4.519