Literature DB >> 19015359

Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains.

Kim Credito1, Gengrong Lin, Laura Koeth, Michael A Sturgess, Peter C Appelbaum.   

Abstract

Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of > or =4 microg/ml).

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Year:  2008        PMID： 19015359      PMCID： PMC2630640          DOI： 10.1128/AAC.01132-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Activities of clinafloxacin, alone and in combination with other compounds, against 45 gram-positive and -negative organisms for which clinafloxacin MICs are high.

Authors:  C L Clark; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

2.  Insect peptides with improved protease-resistance protect mice against bacterial infection.

Authors:  L Otvos; K Bokonyi; I Varga; B I Otvos; R Hoffmann; H C Ertl; J D Wade; A M McManus; D J Craik; P Bulet
Journal:  Protein Sci       Date:  2000-04       Impact factor: 6.725

3.  Development of novel antibacterial peptides that kill resistant isolates.

Authors:  Mare Cudic; Barry A Condie; Daniel J Weiner; Elena S Lysenko; Zhi Q Xiang; O Insug; Philippe Bulet; Laszlo Otvos
Journal:  Peptides       Date:  2002-12       Impact factor: 3.750

Review 4.  Epidemiology and control of antibiotic resistance in the intensive care unit.

Authors:  Jean Carlet; Adel Ben Ali; Annie Chalfine
Journal:  Curr Opin Infect Dis       Date:  2004-08       Impact factor: 4.915

5.  Antipneumococcal activities of cefpirome and cefotaxime, alone and in combination with vancomycin and teicoplanin, determined by checkerboard and time-kill methods.

Authors:  S Bajaksouzian; M A Visalli; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

6.  Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studies.

Authors:  S Bajaksouzian; M A Visalli; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

7.  Comparative activity of trovafloxacin, alone and in combination with other agents, against gram-negative nonfermentative rods.

Authors:  M A Visalli; S Bajaksouzian; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

8.  Comparison of methodologies for synergism testing of drug combinations against resistant strains of Pseudomonas aeruginosa.

Authors:  D M Cappelletty; M J Rybak
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

9.  Prevalence of important pathogens and antimicrobial activity of parenteral drugs at numerous medical centers in the United States, I. Study on the threat of emerging resistances: real or perceived? Fluoroquinolone Resistance Surveillance Group.

Authors:  R N Jones; E N Kehrberg; M E Erwin; S C Anderson
Journal:  Diagn Microbiol Infect Dis       Date:  1994-08       Impact factor: 2.803

10.  Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin.

Authors:  Goran Kragol; Ralf Hoffmann; Michael A Chattergoon; Sandor Lovas; Mare Cudic; Philippe Bulet; Barry A Condie; K Johan Rosengren; Luis J Montaner; Laszlo Otvos
Journal:  Eur J Biochem       Date:  2002-09
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  3 in total

1.  Analysis of the bacterial heat shock response to photodynamic therapy-mediated oxidative stress.

Authors:  Tyler G St Denis; Liyi Huang; Tianhong Dai; Michael R Hamblin
Journal:  Photochem Photobiol       Date:  2011-02-22       Impact factor: 3.421

Review 2.  Targeting the Proteostasis Network for Mycobacterial Drug Discovery.

Authors:  Tania J Lupoli; Julien Vaubourgeix; Kristin Burns-Huang; Ben Gold
Journal:  ACS Infect Dis       Date:  2018-03-02       Impact factor: 5.084

3.  The inactivation of RNase G reduces the Stenotrophomonas maltophilia susceptibility to quinolones by triggering the heat shock response.

Authors:  Alejandra Bernardini; Fernando Corona; Ricardo Dias; Maria B Sánchez; Jose L Martínez
Journal:  Front Microbiol       Date:  2015-10-19       Impact factor: 5.640
  3 in total

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