Literature DB >> 19013893

Molecular targets and biological modifiers in gastric cancer.

Fátima Carneiro1, Carla Oliveira, Marina Leite, Raquel Seruca.   

Abstract

The overall survival of gastric cancer patients remains poor despite efforts and advances in its prevention, diagnosis, and treatment. The development of new therapies is crucial for the effective control of this disease. An increasing number of genetic and epigenetic alterations have been associated with distinct histological types of gastric cancer. In this review, we will discuss the involvement of E-cadherin, EGFR, ERBB2, MMR genes, KRAS, and PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets for therapy.

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Year:  2008        PMID： 19013893     DOI： 10.1053/j.semdp.2008.07.004

Source DB:  PubMed          Journal:  Semin Diagn Pathol        ISSN： 0740-2570            Impact factor:   3.464


  8 in total

1.  Histotype-based prognostic classification of gastric cancer.

Authors:  Anna Maria Chiaravalli; Catherine Klersy; Alessandro Vanoli; Andrea Ferretti; Carlo Capella; Enrico Solcia
Journal:  World J Gastroenterol       Date:  2012-03-07       Impact factor: 5.742

2.  Early-onset gastric cancer: Learning lessons from the young.

Authors:  Anya N Milne; G Johan A Offerhaus
Journal:  World J Gastrointest Oncol       Date:  2010-02-15

3.  Detection of differentially expressed basal cell proteins by mass spectrometry.

Authors:  Viktor Todorović; Bhushan V Desai; Richard A Eigenheer; Taofei Yin; Evangeline V Amargo; Milan Mrksich; Kathleen J Green; Melanie J Schroeder Patterson
Journal:  Mol Cell Proteomics       Date:  2009-11-30       Impact factor: 5.911

4.  Epstein-Barr virus-specific methylation of human genes in gastric cancer cells.

Authors:  Julie L Ryan; Richard J Jones; Shannon C Kenney; Ashley G Rivenbark; Weihua Tang; Elizabeth Rw Knight; William B Coleman; Margaret L Gulley
Journal:  Infect Agent Cancer       Date:  2010-12-31       Impact factor: 2.965

5.  The PD-1, PD-L1 expression and CD3+ T cell infiltration in relation to outcome in advanced gastric signet-ring cell carcinoma, representing a potential biomarker for immunotherapy.

Authors:  Shenying Jin; Bo Xu; Lixia Yu; Yao Fu; Hongyan Wu; Xiangshan Fan; Jia Wei; Baorui Liu
Journal:  Oncotarget       Date:  2017-06-13

6.  Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors.

Authors:  Yongjun Guan; Man Li; Zhendong Qiu; Junhui Xu; Yichao Zhang; Ning Hu; Xuanzhe Zhang; Wenyi Guo; Jingping Yuan; Qiao Shi; Weixing Wang
Journal:  J Adv Res       Date:  2021-06-12       Impact factor: 10.479

Review 7.  Nature meets nurture: molecular genetics of gastric cancer.

Authors:  Anya N Milne; F Carneiro; C O'Morain; G J A Offerhaus
Journal:  Hum Genet       Date:  2009-08-06       Impact factor: 4.132

8.  Genomic profile analysis of diffuse-type gastric cancers.

Authors:  Yeon-Su Lee; Yun Sung Cho; Geon Kook Lee; Sunghoon Lee; Young-Woo Kim; Sungwoong Jho; Hak-Min Kim; Seung-Hyun Hong; Jung-Ah Hwang; Sook-young Kim; Dongwan Hong; Il Ju Choi; Byung Chul Kim; Byoung-Chul Kim; Chul Hong Kim; Hansol Choi; Youngju Kim; Kyung Wook Kim; Gu Kong; Hyung Lae Kim; Jong Bhak; Seung Hoon Lee; Jin Soo Lee
Journal:  Genome Biol       Date:  2014-04-01       Impact factor: 13.583
  8 in total

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