| Literature DB >> 19013135 |
Hisao Ezaki1, Yuichi Yoshida, Yukiko Saji, Takayo Takemura, Juichi Fukushima, Hitoshi Matsumoto, Yoshihiro Kamada, Akira Wada, Takumi Igura, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shinji Tamura, Shinichi Kiso, Norio Hayashi.
Abstract
We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO) mice. We analyzed DNA replication and various signaling pathways involved in cell proliferation and metabolism. Adiponectin KO mice exhibited delayed DNA replication and increased lipid accumulation in the regenerating liver. The expression levels of peroxisome proliferator-activated receptor (PPAR) alpha and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Collectively, the present results highlight a new role for adiponectin in the process of liver regeneration.Entities:
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Year: 2008 PMID： 19013135 DOI： 10.1016/j.bbrc.2008.10.176
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575