| Literature DB >> 19013077 |
Jan Andersson1, Phong Truong, Christer Halldin.
Abstract
The (14)N(rho, alpha)(11)C reaction on N(2)-O(2) or N(2)-H(2) gaseous systems as targets in proton bombardment allows for the production of [(11)C]CO(2) and [(11)C]CH(4.) We report the target production of [(11)C]CH(4) and the gas phase iodination to produce [(11)C]CH(3)I with high specific radioactivity (SA). SA was calculated for four different radiopharmaceuticals produced in-house from both target produced [(11)C]CO(2) and [(11)C]CH(4.) For [(11)C]raclopride we obtained an average SA of 3908 GBq/mumol (106000 Ci/mmol) at the end of bombardment for the last 52 productions, which is a 32-fold increase compared to when using the in-house [(11)C]CO(2) target.Entities:
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Year: 2008 PMID： 19013077 DOI： 10.1016/j.apradiso.2008.09.010
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513