AIM: Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia. METHODS: We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-10. RESULTS: Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-alpha and IL-6 (but not IL-1beta or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure. CONCLUSIONS: We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.
AIM: Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia. METHODS: We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-10. RESULTS: Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-alpha and IL-6 (but not IL-1beta or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure. CONCLUSIONS: We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.
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