Pier Guido Ciabatti1, Luca D'Ascanio. 1. Department of Otorhinolaryngology - Head & Neck Surgery, San Donato Civil Hospital - ASL 8, Arezzo, Italy. p.ciabatti@usl8.toscana.it
Abstract
CONCLUSION: Local Capsicum oleous nasal spray, 4 microg/puff three times a day for 3 consecutive days, is an efficacious and safe treatment for idiopathic rhinitis (IR). Furthermore, being a natural product, Capsicum oleous nasal spray may be readily available for patients. OBJECTIVES: To evaluate the efficacy and safety of different therapeutic regimens of Capsicum oleous nasal spray in IR. PATIENTS AND METHODS: A total of 208 patients affected by IR were enrolled in a randomizedplacebo-controlled trial. Diagnosis of IR was made on the basis of history of nasal obstruction, sneezing and/or rhinorrhoea and after exclusion of other nasal/paranasal anatomic disorders. IR patients were randomized into four groups (groups A, B, and C) receiving increasing doses of Capsicum (1, 2 or 4 microg/puff, respectively) and one group (group D) treated with placebo. Capsicum oleous nasal spray, one puff per nostril, was instilled three times a day at 30 min intervals for 3 consecutive days. Pre- and post-treatment nasal symptoms were evaluated with a daily record chart. RESULTS: A significant reduction in the frequency of IR symptom was noticed in group C (4 microg/puff, three times a day for 3 consecutive days) vs controls (p=0.003). No significant difference in side effects was recorded in patients receiving Capsicum therapy with respect to controls.
RCT Entities:
CONCLUSION: Local Capsicum oleous nasal spray, 4 microg/puff three times a day for 3 consecutive days, is an efficacious and safe treatment for idiopathic rhinitis (IR). Furthermore, being a natural product, Capsicum oleous nasal spray may be readily available for patients. OBJECTIVES: To evaluate the efficacy and safety of different therapeutic regimens of Capsicum oleous nasal spray in IR. PATIENTS AND METHODS: A total of 208 patients affected by IR were enrolled in a randomized placebo-controlled trial. Diagnosis of IR was made on the basis of history of nasal obstruction, sneezing and/or rhinorrhoea and after exclusion of other nasal/paranasal anatomic disorders. IR patients were randomized into four groups (groups A, B, and C) receiving increasing doses of Capsicum (1, 2 or 4 microg/puff, respectively) and one group (group D) treated with placebo. Capsicum oleous nasal spray, one puff per nostril, was instilled three times a day at 30 min intervals for 3 consecutive days. Pre- and post-treatment nasal symptoms were evaluated with a daily record chart. RESULTS: A significant reduction in the frequency of IR symptom was noticed in group C (4 microg/puff, three times a day for 3 consecutive days) vs controls (p=0.003). No significant difference in side effects was recorded in patients receiving Capsicum therapy with respect to controls.
Authors: Koen Van Crombruggen; L Van Nassauw; L Derycke; J-P Timmermans; G Holtappels; D Hall; C Bachert Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2011-04-28 Impact factor: 3.000
Authors: Koosha Ghazi-Moghadam; Hasan Mete Inançlı; Nazanin Bazazy; Peter K Plinkert; Thomas Efferth; Serkan Sertel Journal: Pharmaceuticals (Basel) Date: 2012-08-20