Literature DB >> 19011825

[Are psychic disorders specifically human?].

M Brüne1.   

Abstract

The multifaceted question of whether psychiatric disorders are specific to human beings can not simply be answered "yes" or "no". Tackling the question can nevertheless be important because many symptoms characteristic of human psychiatric disorders can be found in behaviourally abnormal animals. From this perspective therefore the answer must be "no". Research into the environmental causes of such symptoms, for example in our closest extant relatives, the nonhuman primates, can potentially contribute to the prevention of human psychiatric disorders. Moreover, research into animal models of psychiatric disorders has made great progress in terms of both aetiology and (pharmaco-) therapeutic options. Even though the applicability of findings to human disorders is contested, it is hardly ever questioned. In any event, is there anything specific to humans that animal models can not express and that render studies of human experience and behaviour indispensible? The answer can only be "yes" because human experience and behaviour have evolved in a species-typical way. Accordingly, future multidisciplinary research should be thoroughly grounded in the natural sciences, preferably adopting a structure after Tinbergen's four "W" questions on ontogeny, mechanism, phylogeny, and adaptive value.

Entities:  

Mesh:

Year:  2009        PMID: 19011825     DOI: 10.1007/s00115-008-2591-2

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  36 in total

1.  Some pathological processes set in train by early mother-child separation.

Authors:  J BOWLBY
Journal:  J Ment Sci       Date:  1953-04

2.  Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.

Authors:  Takatoshi Hikida; Hanna Jaaro-Peled; Saurav Seshadri; Kenichi Oishi; Caroline Hookway; Stephanie Kong; Di Wu; Rong Xue; Manuella Andradé; Stephanie Tankou; Susumu Mori; Michela Gallagher; Koko Ishizuka; Mikhail Pletnikov; Satoshi Kida; Akira Sawa
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-03       Impact factor: 11.205

Review 3.  Psychopathology in great apes: concepts, treatment options and possible homologies to human psychiatric disorders.

Authors:  Martin Brüne; Ute Brüne-Cohrs; William C McGrew; Signe Preuschoft
Journal:  Neurosci Biobehav Rev       Date:  2006-12-01       Impact factor: 8.989

Review 4.  Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?

Authors:  Nicole M Talge; Charles Neal; Vivette Glover
Journal:  J Child Psychol Psychiatry       Date:  2007 Mar-Apr       Impact factor: 8.982

5.  Rehabilitation of research chimpanzees: stress and coping after long-term isolation.

Authors:  Michaela Reimers; Franz Schwarzenberger; Signe Preuschoft
Journal:  Horm Behav       Date:  2007-01-03       Impact factor: 3.587

6.  Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys.

Authors:  Gary S Linn; Shobhit S Negi; Scott V Gerum; Daniel C Javitt
Journal:  Psychopharmacology (Berl)       Date:  2003-07-04       Impact factor: 4.530

7.  Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Authors:  Avshalom Caspi; Karen Sugden; Terrie E Moffitt; Alan Taylor; Ian W Craig; HonaLee Harrington; Joseph McClay; Jonathan Mill; Judy Martin; Antony Braithwaite; Richie Poulton
Journal:  Science       Date:  2003-07-18       Impact factor: 47.728

Review 8.  Meat-adaptive genes and the evolution of slower aging in humans.

Authors:  Caleb E Finch; Craig B Stanford
Journal:  Q Rev Biol       Date:  2004-03       Impact factor: 4.875

9.  Injections of NGF into neonatal frontal cortex decrease social interaction as adults: a rat model of schizophrenia.

Authors:  Noah L Lazar; Nagalingam Rajakumar; Donald Peter Cain
Journal:  Schizophr Bull       Date:  2007-05-24       Impact factor: 9.306

10.  Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment.

Authors:  Andreas Reif; Michael Rösler; Christine M Freitag; Marc Schneider; Andrea Eujen; Christian Kissling; Denise Wenzler; Christian P Jacob; Petra Retz-Junginger; Johannes Thome; Klaus-Peter Lesch; Wolfgang Retz
Journal:  Neuropsychopharmacology       Date:  2007-03-07       Impact factor: 7.853

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