Literature DB >> 19011376

PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus.

Giovanna Musco1, Pärt Peterson.   

Abstract

Methylation of lysine residues on histone H3 tails regulates transcription. A recent addition to the list of known methylated histone binding modules is the plant homeodomain (PHD) finger, which is usually found in nuclear proteins with chromatin-related functions. Autoimmune regulator (AIRE) protein contains two PHD fingers and mutations in AIRE gene cause the monogenic disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). AIRE is expressed in thymic medullary epithelial cells where it promotes the expression of tissue-specific antigens. However the mechanism by which AIRE controls gene expression is currently unknown and the function of its domains, in particular of its PHD fingers is still elusive and controversial. In this review we discuss recent works on AIRE PHD finger(s) providing a new link between the status of histone modifications and the regulation of tissue-specific antigen expression in thymus.

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Year:  2008        PMID： 19011376      PMCID： PMC2635555          DOI： 10.4161/epi.3.6.7182

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  39 in total

Review 1.  Chromatin modifications and their function.

Authors:  Tony Kouzarides
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

2.  Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.

Authors:  Hugo van Ingen; Frederik M A van Schaik; Hans Wienk; Joost Ballering; Holger Rehmann; Annemarie C Dechesne; John A W Kruijzer; Rob M J Liskamp; H Th Marc Timmers; Rolf Boelens
Journal:  Structure       Date:  2008-08-06       Impact factor: 5.006

Review 3.  Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity.

Authors:  Pärt Peterson; Leena Peltonen
Journal:  J Autoimmun       Date:  2005-11-14       Impact factor: 7.094

Review 4.  Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.

Authors:  Alexander J Ruthenburg; C David Allis; Joanna Wysocka
Journal:  Mol Cell       Date:  2007-01-12       Impact factor: 17.970

5.  The autoimmune regulator (AIRE) is a DNA-binding protein.

Authors:  P G Kumar; M Laloraya; C Y Wang; Q G Ruan; A Davoodi-Semiromi; K J Kao; J X She
Journal:  J Biol Chem       Date:  2001-08-31       Impact factor: 5.157

6.  APECED-causing mutations in AIRE reveal the functional domains of the protein.

Authors:  Maria Halonen; Hannele Kangas; Taina Rüppell; Tanja Ilmarinen; Juha Ollila; Meelis Kolmer; Mauno Vihinen; Jorma Palvimo; Jani Saarela; Ismo Ulmanen; Petra Eskelin
Journal:  Hum Mutat       Date:  2004-03       Impact factor: 4.878

Review 7.  The multi-tasking P-TEFb complex.

Authors:  Vanessa Brès; Sunnie M Yoh; Katherine A Jones
Journal:  Curr Opin Cell Biol       Date:  2008-05-29       Impact factor: 8.382

8.  DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.

Authors:  Steen K T Ooi; Chen Qiu; Emily Bernstein; Keqin Li; Da Jia; Zhe Yang; Hediye Erdjument-Bromage; Paul Tempst; Shau-Ping Lin; C David Allis; Xiaodong Cheng; Timothy H Bestor
Journal:  Nature       Date:  2007-08-09       Impact factor: 49.962

9.  NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.

Authors:  Matthew James Bottomley; Gunter Stier; Danilo Pennacchini; Gaelle Legube; Bernd Simon; Asifa Akhtar; Michael Sattler; Giovanna Musco
Journal:  J Biol Chem       Date:  2005-01-13       Impact factor: 5.157

10.  ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

Authors:  Xiaobing Shi; Tao Hong; Kay L Walter; Mark Ewalt; Eriko Michishita; Tiffany Hung; Dylan Carney; Pedro Peña; Fei Lan; Mohan R Kaadige; Nicolas Lacoste; Christelle Cayrou; Foteini Davrazou; Anjanabha Saha; Bradley R Cairns; Donald E Ayer; Tatiana G Kutateladze; Yang Shi; Jacques Côté; Katrin F Chua; Or Gozani
Journal:  Nature       Date:  2006-05-21       Impact factor: 49.962
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  12 in total

1.  DAXX is a new AIRE-interacting protein.

Authors:  Alessandra Meloni; Allesandra Meloni; Edoardo Fiorillo; Denise Corda; Federica Incani; Maria Luisa Serra; Antonella Contini; Antonio Cao; Maria Cristina Rosatelli
Journal:  J Biol Chem       Date:  2010-02-25       Impact factor: 5.157

Review 2.  Control of central and peripheral tolerance by Aire.

Authors:  Todd C Metzger; Mark S Anderson
Journal:  Immunol Rev       Date:  2011-05       Impact factor: 12.988

Review 3.  Update on Aire and thymic negative selection.

Authors:  Geraldo A Passos; Cesar A Speck-Hernandez; Amanda F Assis; Daniella A Mendes-da-Cruz
Journal:  Immunology       Date:  2017-09-26       Impact factor: 7.397

4.  Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

Authors:  Andrew S Koh; Robert E Kingston; Christophe Benoist; Diane Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-06       Impact factor: 11.205

Review 5.  Aire and T cell development.

Authors:  Mark S Anderson; Maureen A Su
Journal:  Curr Opin Immunol       Date:  2010-12-14       Impact factor: 7.486

Review 6.  Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".

Authors:  Samuel S Oliver; John M Denu
Journal:  Chembiochem       Date:  2010-10-29       Impact factor: 3.164

7.  Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model?

Authors:  Mitsuru Matsumoto; Yumiko Nishikawa; Hitoshi Nishijima; Junko Morimoto; Minoru Matsumoto; Yasuhiro Mouri
Journal:  Front Immunol       Date:  2013-07-22       Impact factor: 7.561

8.  AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.

Authors:  Massimiliano Gaetani; Vittoria Matafora; Mario Saare; Dimitrios Spiliotopoulos; Luca Mollica; Giacomo Quilici; Francesca Chignola; Valeria Mannella; Chiara Zucchelli; Pärt Peterson; Angela Bachi; Giovanna Musco
Journal:  Nucleic Acids Res       Date:  2012-10-15       Impact factor: 16.971

9.  The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.

Authors:  Francesca Chignola; Massimiliano Gaetani; Ana Rebane; Tõnis Org; Luca Mollica; Chiara Zucchelli; Andrea Spitaleri; Valeria Mannella; Pärt Peterson; Giovanna Musco
Journal:  Nucleic Acids Res       Date:  2009-03-17       Impact factor: 16.971

10.  Differential transcript profiles of MHC class Ib(Qa-1, Qa-2, and Qa-10) and Aire genes during the ontogeny of thymus and other tissues.

Authors:  Breno Luiz Melo-Lima; Adriane Feijó Evangelista; Danielle Aparecida Rosa de Magalhães; Geraldo Aleixo Passos; Philippe Moreau; Eduardo Antonio Donadi
Journal:  J Immunol Res       Date:  2014-04-16       Impact factor: 4.818
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