Literature DB >> 19011257

The LDL modification hypothesis of atherogenesis: an update.

Daniel Steinberg1.   

Abstract

The accumulated evidence that oxidative modification of LDL plays an important role in the pathogenesis of atherosclerosis in animal models is very strong. The negative results in recent clinical studies have caused many to conclude that LDL oxidation may not be relevant in the human disease. Yet many of the lines of evidence that support the hypothesis have been demonstrated to apply also in humans. In this review, we briefly summarize the lines of evidence on which the hypothesis rests, its strengths, and its weaknesses.

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Year:  2008        PMID： 19011257      PMCID： PMC2674707          DOI： 10.1194/jlr.R800087-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  49 in total

Review 1.  Atherosclerosis. the road ahead.

Authors:  C K Glass; J L Witztum
Journal:  Cell       Date:  2001-02-23       Impact factor: 41.582

Review 2.  Scavenger receptors, oxidized LDL, and atherosclerosis.

Authors:  A Boullier; D A Bird; M K Chang; E A Dennis; P Friedman; K Gillotre-Taylor; S Hörkkö; W Palinski; O Quehenberger; P Shaw; D Steinberg; V Terpstra; J L Witztum
Journal:  Ann N Y Acad Sci       Date:  2001-12       Impact factor: 5.691

3.  Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.

Authors:  D M Shih; Y R Xia; X P Wang; E Miller; L W Castellani; G Subbanagounder; H Cheroutre; K F Faull; J A Berliner; J L Witztum; A J Lusis
Journal:  J Biol Chem       Date:  2000-06-09       Impact factor: 5.157

4.  Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice.

Authors:  Robert J Aiello; Patricia-Ann Bourassa; Saralyn Lindsey; Weifan Weng; Ann Freeman; Henry J Showell
Journal:  Arterioscler Thromb Vasc Biol       Date:  2002-03-01       Impact factor: 8.311

Review 5.  Immune mechanisms in atherosclerosis.

Authors:  G K Hansson
Journal:  Arterioscler Thromb Vasc Biol       Date:  2001-12       Impact factor: 8.311

6.  Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.

Authors:  T Cyrus; J L Witztum; D J Rader; R Tangirala; S Fazio; M F Linton; C D Funk
Journal:  J Clin Invest       Date:  1999-06       Impact factor: 14.808

7.  Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice.

Authors:  D Harats; A Shaish; J George; M Mulkins; H Kurihara; H Levkovitz; E Sigal
Journal:  Arterioscler Thromb Vasc Biol       Date:  2000-09       Impact factor: 8.311

8.  Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial.

Authors:  M Boaz; S Smetana; T Weinstein; Z Matas; U Gafter; A Iaina; A Knecht; Y Weissgarten; D Brunner; M Fainaru; M S Green
Journal:  Lancet       Date:  2000-10-07       Impact factor: 79.321

9.  Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice.

Authors:  T Cyrus; D Praticò; L Zhao; J L Witztum; D J Rader; J Rokach; G A FitzGerald; C D Funk
Journal:  Circulation       Date:  2001-05-08       Impact factor: 29.690

10.  12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice.

Authors:  J George; A Afek; A Shaish; H Levkovitz; N Bloom; T Cyrus; L Zhao; C D Funk; E Sigal; D Harats
Journal:  Circulation       Date:  2001-10-02       Impact factor: 29.690
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  109 in total

Review 1.  Regulation of lipid stores and metabolism by lipophagy.

Authors:  K Liu; M J Czaja
Journal:  Cell Death Differ       Date:  2012-05-18       Impact factor: 15.828

Review 2.  Myeloid cells in atherosclerosis: initiators and decision shapers.

Authors:  Oliver Soehnlein; Christian Weber
Journal:  Semin Immunopathol       Date:  2009-02-24       Impact factor: 9.623

3.  Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

Authors:  Pierre Rotzius; Sebastian Thams; Oliver Soehnlein; Ellinor Kenne; Chi-Nan Tseng; Niklas K Björkström; Karl-Johan Malmberg; Lennart Lindbom; Einar E Eriksson
Journal:  Am J Pathol       Date:  2010-05-14       Impact factor: 4.307

4.  Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions.

Authors:  Patrick M Hutchins; Ernest E Moore; Robert C Murphy
Journal:  J Lipid Res       Date:  2011-08-31       Impact factor: 5.922

5.  Near-infrared fluorescence imaging of murine atherosclerosis using an oxidized low density lipoprotein-targeted fluorochrome.

Authors:  Tong Lu; Song Wen; Ying Cui; Sheng-Hong Ju; King C Li; Gao-Jun Teng
Journal:  Int J Cardiovasc Imaging       Date:  2013-10-30       Impact factor: 2.357

Review 6.  The immune system in atherosclerosis.

Authors:  Göran K Hansson; Andreas Hermansson
Journal:  Nat Immunol       Date:  2011-03       Impact factor: 25.606

7.  Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.

Authors:  Mahmoud Merhi; Sally Demirdjian; Essa Hariri; Nada Sabbah; Sonia Youhanna; Michella Ghassibe-Sabbagh; Joseph Naoum; Marc Haber; Raed Othman; Samer Kibbani; Elie Chammas; Roy Kanbar; Hamid El Bayeh; Youssef Chami; Antoine Abchee; Daniel E Platt; Pierre Zalloua; Georges Khazen
Journal:  Inflamm Res       Date:  2015-04-24       Impact factor: 4.575

8.  Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry.

Authors:  Tuyen N Tran; Malathi G Kosaraju; Shiori Tamamizu-Kato; Olayemi Akintunde; Ying Zheng; John K Bielicki; Kent Pinkerton; Koji Uchida; Yuan Yu Lee; Vasanthy Narayanaswami
Journal:  Biochemistry       Date:  2014-01-08       Impact factor: 3.162

9.  Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes.

Authors:  Carrie J Finno; Matthew H Bordbari; Stephanie J Valberg; David Lee; Josi Herron; Kelly Hines; Tamer Monsour; Erica Scott; Danika L Bannasch; James Mickelson; Libin Xu
Journal:  Free Radic Biol Med       Date:  2016-10-15       Impact factor: 7.376

10.  Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs.

Authors:  Malene M Birck; Antti Saraste; Poul Hyttel; Michal Odermarsky; Petru Liuba; Pekka Saukko; Axel K Hansen; Erkki Pesonen
Journal:  J Cardiovasc Transl Res       Date:  2013-04-12       Impact factor: 4.132
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