| Literature DB >> 19010671 |
William L Mitchell1, Gerard M P Giblin, Alan Naylor, Andrew J Eatherton, Brian P Slingsby, Anthony D Rawlings, Karamjit S Jandu, Carl P Haslam, Andrew J Brown, Paul Goldsmith, Nick M Clayton, Alex W Wilson, Iain P Chessell, Richard H Green, Andrew R Whittington, Ian D Wall.
Abstract
We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB(2) receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflammatory pain.Entities:
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Year: 2008 PMID： 19010671 DOI： 10.1016/j.bmcl.2008.10.118
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823