Literature DB >> 19010569

Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines.

Mehmet Alp1, Hakan Göker, Reto Brun, Sulhiye Yildiz.   

Abstract

A series of 2'-arylsubstituted-1H,1'H-[2,5']-bisbenzimidazolyl-5-carboxamidines were prepared in a six-step process starting from 4-amino-3-nitrobenzonitrile. The antiparasitic activity against Trypanosoma brucei rhodesiense (T.b.r.), Plasmodium falciparum (P.f.), Leishmania donovani (L.d.) and Trypanosoma cruzi (T.c.) and antifungal activity against Candida albicans and Candida krusei were evaluated in vitro. Several compounds showed promising in vitro activity against T.b.r., P.f. and C. albicans and had superior activity against P.f. as compared to chloroquine.

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Year:  2008        PMID： 19010569     DOI： 10.1016/j.ejmech.2008.10.003

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

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Authors:  Reham A I Abou-Elkhair; Abdalla E A Hassan; David W Boykin; W David Wilson
Journal:  Org Lett       Date:  2016-09-08       Impact factor: 6.005

2.  Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens.

Authors:  Christopher A Rice; Beatrice L Colon; Mehmet Alp; Hakan Göker; David W Boykin; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2015-01-20       Impact factor: 5.191

3.  Evaluation of the Antioxidant Activity of Some Imines Containing 1H-Benzimidazoles.

Authors:  Rahman Başaran; Gülgün Kılcıgil; Benay Eke
Journal:  Turk J Pharm Sci       Date:  2020-12-23

4.  New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFRWT and EGFRT790M Inhibitors: Microwave-Assisted Synthesis, Anticancer Evaluation, and Molecular Docking Study.

Authors:  Heba E Hashem; Abd El-Galil E Amr; Eman S Nossier; Manal M Anwar; Eman M Azmy
Journal:  ACS Omega       Date:  2022-02-18

5.  DNA Cleavage and Condensation Activities of Mono- and Binuclear Hybrid Complexes and Regulation by Graphene Oxide.

Authors:  Shuo Li; Mingxing Dai; Chunping Zhang; Bingying Jiang; Junqiang Xu; Dewen Zhou; Zhongwei Gu
Journal:  Molecules       Date:  2016-07-15       Impact factor: 4.411

6.  Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Authors:  Andrea Bistrović; Luka Krstulović; Ivana Stolić; Domagoj Drenjančević; Jasminka Talapko; Martin C Taylor; John M Kelly; Miroslav Bajić; Silvana Raić-Malić
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  6 in total

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