| Literature DB >> 19010439 |
Leigh A Jania1, Subhashini Chandrasekharan, Michael G Backlund, Nicholas A Foley, John Snouwaert, I-Ming Wang, Patsy Clark, Laurent P Audoly, Beverly H Koller.
Abstract
Prostaglandin E(2) (PGE(2)) plays an important role in the normal physiology of many organ systems. Increased levels of this lipid mediator are associated with many disease states, and it potently regulates inflammatory responses. Three enzymes capable of in vitro synthesis of PGE(2) from the cyclooxygenase metabolite PGH(2) have been described. Here, we examine the contribution of one of these enzymes to PGE(2) production, mPges-2, which encodes microsomal prostaglandin synthase-2 (mPGES-2), by generating mice homozygous for the null allele of this gene. Loss of mPges-2 expression did not result in a measurable decrease in PGE(2) levels in any tissue or cell type examined from healthy mice. Taken together, analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase.Entities:
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Year: 2008 PMID： 19010439 PMCID： PMC3182462 DOI： 10.1016/j.prostaglandins.2008.10.003
Source DB: PubMed Journal: Prostaglandins Other Lipid Mediat ISSN： 1098-8823 Impact factor: 3.072