OBJECTIVES: Paediatric patients are a special group in apheresis. It is general accepted to use adult indications in paediatric patients, but data in this age group are rare. In order to provide more information of apheresis practise in children and young adults (<21a) we will report of knowledge learnt by data from the registry from 2003 until 2007. METHODS: This is a web-based registry. A link is available from the WAA homepage (www.worldapheresis.org). So far data from 12,448 procedures have been included. Six hundred and twelve procedures were performed in 135 children and young adults (308 procedures<16a, 237 from 17 to 20a, and 67 with 21a) representing 5% of the total population. The median age was 14 years (range 1-21 years), 74 male and 61 female. These data were entered by 15 centres with a frequency of in median 18 aphereses in young patients per centre (range 1-287) from 2003 to 2007. RESULTS: Main indications: haematological diseases and also nephrological, and neurological. The type of aphereses was mainly Leukapheresis (196, 33%), plasma exchange (149, 25%), photopheresis (127, 21%), and lipid aphereses (79, 13%). Blood access: peripheral vessels in 305 procedures (50%, compared to 73% in adults), central venous catheter in 239 (38%), and AV-fistula in 2% and 0.3%, and in 8 (1.31%) procedures an arterial line was used. Anticoagulation was mostly by ACD (71%), heparin (18% or the combination of both (3%). 39 adverse events (AE) were registered in 22 (=3.59%) of the procedures, mostly graded as mild. Treatment was interrupted in 14 procedures (2.29%). AE's were abdominal pain, anaphylactic shock, flush, hyper- and hypotension, nausea, vertigo, cephalea and need for sedation and technical problems with the device and problems with the venous access. The rate of AE's was similar for stem cell harvesting and for plasma exchange (4% and 4.7%, respectively). CONCLUSION: The paediatric data compared to the whole registry data set are showing that aphereses are performed as safe in paediatrics as in adults. Centres are mostly handling only a few cases younger than 21. Therefore more exchange of information and experience in paediatric apheresis is warranted.
OBJECTIVES: Paediatric patients are a special group in apheresis. It is general accepted to use adult indications in paediatric patients, but data in this age group are rare. In order to provide more information of apheresis practise in children and young adults (<21a) we will report of knowledge learnt by data from the registry from 2003 until 2007. METHODS: This is a web-based registry. A link is available from the WAA homepage (www.worldapheresis.org). So far data from 12,448 procedures have been included. Six hundred and twelve procedures were performed in 135 children and young adults (308 procedures<16a, 237 from 17 to 20a, and 67 with 21a) representing 5% of the total population. The median age was 14 years (range 1-21 years), 74 male and 61 female. These data were entered by 15 centres with a frequency of in median 18 aphereses in young patients per centre (range 1-287) from 2003 to 2007. RESULTS: Main indications: haematological diseases and also nephrological, and neurological. The type of aphereses was mainly Leukapheresis (196, 33%), plasma exchange (149, 25%), photopheresis (127, 21%), and lipid aphereses (79, 13%). Blood access: peripheral vessels in 305 procedures (50%, compared to 73% in adults), central venous catheter in 239 (38%), and AV-fistula in 2% and 0.3%, and in 8 (1.31%) procedures an arterial line was used. Anticoagulation was mostly by ACD (71%), heparin (18% or the combination of both (3%). 39 adverse events (AE) were registered in 22 (=3.59%) of the procedures, mostly graded as mild. Treatment was interrupted in 14 procedures (2.29%). AE's were abdominal pain, anaphylactic shock, flush, hyper- and hypotension, nausea, vertigo, cephalea and need for sedation and technical problems with the device and problems with the venous access. The rate of AE's was similar for stem cell harvesting and for plasma exchange (4% and 4.7%, respectively). CONCLUSION: The paediatric data compared to the whole registry data set are showing that aphereses are performed as safe in paediatrics as in adults. Centres are mostly handling only a few cases younger than 21. Therefore more exchange of information and experience in paediatric apheresis is warranted.
Authors: Fabio Paglialonga; Claus Peter Schmitt; Rukshana Shroff; Karel Vondrak; Christoph Aufricht; Alan Rees Watson; Gema Ariceta; Michael Fischbach; Gunter Klaus; Tuula Holtta; Sevcan A Bakkaloglu; Alexandra Zurowska; Augustina Jankauskiene; Johan Vande Walle; Betti Schaefer; Elizabeth Wright; Roy Connell; Alberto Edefonti Journal: Pediatr Nephrol Date: 2014-08-20 Impact factor: 3.714
Authors: Martin Kreuzer; Thurid Ahlenstiel; Nele Kanzelmeyer; Jochen H H Ehrich; Lars Pape Journal: Pediatr Nephrol Date: 2010-10-21 Impact factor: 3.714
Authors: Bernd Stegmayr; Elizabeth Newman; Volker Witt; Kurt Derfler; Gerda Leitner; Sunny Eloot; Annemieke Dhondt; Dries Deeren; Jan Ptak; Milan Blaha; Mirka Lanska; Zdenka Gasova; Zdenka Bhuiyan-Ludvikova; Radomira Hrdlickova; Wolfgang Ramlow; Heinrich Prophet; Jan T Kielstein; Giancarlo Liumbruno; Elena Mori; Antanas Griskevicius; Judita Audzijoniene; Hans Vrielink; Eva Rombout-Sestrienkova; Astrid Aandahl; Aleksandar Sikole; Jorge Tomaz; Katarina Lalic; Ines Bojanic; Virginia Strineholm; Bo Brink; Gösta Berlin; Josefina Dykes; Thomas Nilsson; Torsten Eich; Henrik Hadimeri; Gunilla Welander; Sandra Ortega Sanchez; Osman Ilhan; Colwyn Poole Journal: Transfus Med Hemother Date: 2021-01-05 Impact factor: 3.747
Authors: Simone de Campos Vieira Abib; Chan Hon Chui; Sharon Cox; Abdelhafeez H Abdelhafeez; Israel Fernandez-Pineda; Ahmed Elgendy; Jonathan Karpelowsky; Pablo Lobos; Marc Wijnen; Jörg Fuchs; Andrea Hayes; Justin T Gerstle Journal: Ecancermedicalscience Date: 2022-02-17
Authors: Sally Johnson; Jelena Stojanovic; Gema Ariceta; Martin Bitzan; Nesrin Besbas; Michelle Frieling; Diana Karpman; Daniel Landau; Craig Langman; Christoph Licht; Carmine Pecoraro; Magdalena Riedl; Ekaterini Siomou; Nicole van de Kar; Johan Vande Walle; Chantal Loirat; C Mark Taylor Journal: Pediatr Nephrol Date: 2014-05-11 Impact factor: 3.714