OBJECTIVES: (1) To examine trends in serogroup-specific invasive meningococcal disease (IMD) incidence associated with the protein-polysaccharide conjugate C vaccine (MCC) program in BC; (2) To assess for evidence of capsule switching and serogroup replacement; (3) To discuss whether recent data support modification of the current MCC program to include the quadrivalent protein-polysaccharide conjugate vaccine (MCV-4). METHODS: Information on IMD cases since 1998 were extracted from surveillance databases. Annual IMD incidence rates and corresponding three-year moving averages were calculated. Data management was performed using Microsoft Office Excel 2003. Time trends were analyzed using chi-square test for linear trend. RESULTS: For 2003-2006, no significant trends were found in rates of serogroup-specific or total IMD in the overall BC population. Among children <18 years, average annual incidence of serogroup-C IMD has declined with a downward trend (p=0.05). Median age of serogroup-C IMD increased from 16 years (2003) to 42 years (2006). No significant change in incidence rates of pediatric IMD from any non-C serogroup was detected. DISCUSSION: We document a decreasing trend of pediatric serogroup-C IMD and an increase in median age of serogroup-C IMD cases since 2003, most likely explained by protection from immunization. While the proportion of serogroup-Y IMD has increased, incidence rates of non-C vaccine-preventable IMD have not increased in BC. While incorporation of MCV-4 in routine childhood immunization is desirable to address the few residual cases of non-C vaccine-preventable IMD, it would take several decades to appreciate a benefit from a modified childhood program.
OBJECTIVES: (1) To examine trends in serogroup-specific invasive meningococcal disease (IMD) incidence associated with the protein-polysaccharide conjugate C vaccine (MCC) program in BC; (2) To assess for evidence of capsule switching and serogroup replacement; (3) To discuss whether recent data support modification of the current MCC program to include the quadrivalent protein-polysaccharide conjugate vaccine (MCV-4). METHODS: Information on IMD cases since 1998 were extracted from surveillance databases. Annual IMD incidence rates and corresponding three-year moving averages were calculated. Data management was performed using Microsoft Office Excel 2003. Time trends were analyzed using chi-square test for linear trend. RESULTS: For 2003-2006, no significant trends were found in rates of serogroup-specific or total IMD in the overall BC population. Among children <18 years, average annual incidence of serogroup-C IMD has declined with a downward trend (p=0.05). Median age of serogroup-C IMD increased from 16 years (2003) to 42 years (2006). No significant change in incidence rates of pediatric IMD from any non-C serogroup was detected. DISCUSSION: We document a decreasing trend of pediatric serogroup-C IMD and an increase in median age of serogroup-C IMD cases since 2003, most likely explained by protection from immunization. While the proportion of serogroup-Y IMD has increased, incidence rates of non-C vaccine-preventable IMD have not increased in BC. While incorporation of MCV-4 in routine childhood immunization is desirable to address the few residual cases of non-C vaccine-preventable IMD, it would take several decades to appreciate a benefit from a modified childhood program.
Authors: Myint Tin Tin Htar; Sally Jackson; Paul Balmer; Lidia Cristina Serra; Andrew Vyse; Mary Slack; Margarita Riera-Montes; David L Swerdlow; Jamie Findlow Journal: BMC Public Health Date: 2020-12-09 Impact factor: 3.295
Authors: Sandra Guedes; Isabelle Bertrand-Gerentes; Keith Evans; Florence Coste; Philipp Oster Journal: BMC Public Health Date: 2022-02-23 Impact factor: 3.295