| Literature DB >> 19009289 |
Marie-Laure Endale Ahanda1, Thomas Ruby, Håkan Wittzell, Bertrand Bed'Hom, Anne-Marie Chaussé, Veronique Morin, Anne Oudin, Catherine Chevalier, John R Young, Rima Zoorob.
Abstract
Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.Entities:
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Year: 2008 PMID： 19009289 DOI： 10.1007/s00251-008-0337-8
Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846