Literature DB >> 19008896

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance.

Pärt Peterson1, Tõnis Org, Ana Rebane.   

Abstract

The negative selection of T cells in the thymus is necessary for the maintenance of self tolerance. Medullary thymic epithelial cells have a key function in this process as they express a large number of tissue-specific self antigens that are presented to developing T cells. Mutations in the autoimmune regulator (AIRE) protein cause a breakdown of central tolerance that is associated with decreased expression of self antigens in the thymus. In this Review, we discuss the role of AIRE in the thymus and recent advances in our understanding of how AIRE might function at the molecular level to regulate gene expression.

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Year:  2008        PMID： 19008896      PMCID： PMC2785478          DOI： 10.1038/nri2450

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  136 in total

Review 1.  Negative selection--clearing out the bad apples from the T-cell repertoire.

Authors:  Ed Palmer
Journal:  Nat Rev Immunol       Date:  2003-05       Impact factor: 53.106

Review 2.  The coactivator LXXLL nuclear receptor recognition motif.

Authors:  R S Savkur; T P Burris
Journal:  J Pept Res       Date:  2004-03

3.  Cooperative activation of transcription by autoimmune regulator AIRE and CBP.

Authors:  J Pitkänen; A Rebane; J Rowell; A Murumägi; P Ströbel; K Möll; M Saare; J Heikkilä; V Doucas; A Marx; P Peterson
Journal:  Biochem Biophys Res Commun       Date:  2005-08-05       Impact factor: 3.575

4.  Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions.

Authors:  Paola Lo Surdo; Matthew J Bottomley; Michael Sattler; Klaus Scheffzek
Journal:  Mol Endocrinol       Date:  2003-04-17

Review 5.  Of mice and not men: differences between mouse and human immunology.

Authors:  Javier Mestas; Christopher C W Hughes
Journal:  J Immunol       Date:  2004-03-01       Impact factor: 5.422

6.  APECED-causing mutations in AIRE reveal the functional domains of the protein.

Authors:  Maria Halonen; Hannele Kangas; Taina Rüppell; Tanja Ilmarinen; Juha Ollila; Meelis Kolmer; Mauno Vihinen; Jorma Palvimo; Jani Saarela; Ismo Ulmanen; Petra Eskelin
Journal:  Hum Mutat       Date:  2004-03       Impact factor: 4.878

7.  NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

Authors:  Fumiko Kajiura; Shijie Sun; Takashi Nomura; Keisuke Izumi; Tomoo Ueno; Yoshimi Bando; Noriyuki Kuroda; Hongwei Han; Yi Li; Akemi Matsushima; Yousuke Takahama; Shimon Sakaguchi; Tasuku Mitani; Mitsuru Matsumoto
Journal:  J Immunol       Date:  2004-02-15       Impact factor: 5.422

8.  Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.

Authors:  Jens Derbinski; Jana Gäbler; Benedikt Brors; Sascha Tierling; Sunitha Jonnakuty; Manfred Hergenhahn; Leena Peltonen; Jörn Walter; Bruno Kyewski
Journal:  J Exp Med       Date:  2005-06-27       Impact factor: 14.307

9.  AIRE functions as an E3 ubiquitin ligase.

Authors:  Daisuke Uchida; Shigetsugu Hatakeyama; Akemi Matsushima; Hongwei Han; Satoshi Ishido; Hak Hotta; Jun Kudoh; Nobuyoshi Shimizu; Vassilis Doucas; Keiichi I Nakayama; Noriyuki Kuroda; Mitsuru Matsumoto
Journal:  J Exp Med       Date:  2004-01-19       Impact factor: 14.307

10.  Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.

Authors:  Jörn Gotter; Benedikt Brors; Manfred Hergenhahn; Bruno Kyewski
Journal:  J Exp Med       Date:  2004-01-19       Impact factor: 14.307
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  92 in total

1.  Intranodal interaction with dendritic cells dynamically regulates surface expression of the co-stimulatory receptor CD226 protein on murine T cells.

Authors:  Sebastian Seth; Quan Qiu; Simon Danisch; Michael K Maier; Asolina Braun; Inga Ravens; Niklas Czeloth; Rebecca Hyde; Oliver Dittrich-Breiholz; Reinhold Förster; Günter Bernhardt
Journal:  J Biol Chem       Date:  2011-09-21       Impact factor: 5.157

2.  Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance.

Authors:  Maria Hinterberger; Martin Aichinger; Olivia Prazeres da Costa; David Voehringer; Reinhard Hoffmann; Ludger Klein
Journal:  Nat Immunol       Date:  2010-05-02       Impact factor: 25.606

3.  Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells.

Authors:  Lars-Oliver Tykocinski; Anna Sinemus; Esmail Rezavandy; Yanina Weiland; David Baddeley; Christoph Cremer; Stephan Sonntag; Klaus Willecke; Jens Derbinski; Bruno Kyewski
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-21       Impact factor: 11.205

Review 4.  The role of Aire in clonal selection.

Authors:  Ruth T Taniguchi; Mark S Anderson
Journal:  Immunol Cell Biol       Date:  2010-11-16       Impact factor: 5.126

5.  Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.

Authors:  Hideyuki Yoshida; Kushagra Bansal; Uwe Schaefer; Trevor Chapman; Inmaculada Rioja; Irina Proekt; Mark S Anderson; Rab K Prinjha; Alexander Tarakhovsky; Christophe Benoist; Diane Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-27       Impact factor: 11.205

6.  Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.

Authors:  Kristina Žumer; Audrey K Low; Huimin Jiang; Kalle Saksela; B Matija Peterlin
Journal:  Mol Cell Biol       Date:  2012-02-06       Impact factor: 4.272

Review 7.  Antigen presentation in the thymus for positive selection and central tolerance induction.

Authors:  Ludger Klein; Maria Hinterberger; Gerald Wirnsberger; Bruno Kyewski
Journal:  Nat Rev Immunol       Date:  2009-12       Impact factor: 53.106

8.  The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.

Authors:  Anna Chuprin; Ayelet Avin; Yael Goldfarb; Yonatan Herzig; Ben Levi; Adi Jacob; Asaf Sela; Shir Katz; Moran Grossman; Clotilde Guyon; Moran Rathaus; Haim Y Cohen; Irit Sagi; Matthieu Giraud; Michael W McBurney; Eystein S Husebye; Jakub Abramson
Journal:  Nat Immunol       Date:  2015-05-25       Impact factor: 25.606

9.  Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.

Authors:  Suvobrata Chakravarty; Lei Zeng; Ming-Ming Zhou
Journal:  Structure       Date:  2009-05-13       Impact factor: 5.006

10.  AIRE activated tissue specific genes have histone modifications associated with inactive chromatin.

Authors:  Tõnis Org; Ana Rebane; Kai Kisand; Martti Laan; Uku Haljasorg; Reidar Andreson; Pärt Peterson
Journal:  Hum Mol Genet       Date:  2009-09-10       Impact factor: 6.150
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