Literature DB >> 19008408

Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.

Silvia Colussi1, Gabriele Vaccari2, Cristiana Maurella1, Cristina Bona1, Raniero Lorenzetti3, Pasquale Troiano4, Francesco Casalinuovo5, Alessandra Di Sarno6, Maria Grazia Maniaci1, Fabio Zuccon1, Romolo Nonno2, Cristina Casalone1, Maria Mazza1, Giuseppe Ru1, Maria Caramelli1, Umberto Agrimi2, Pier Luigi Acutis1.   

Abstract

Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here, a case-control study was carried out on eight Nor98-positive goats and 246 negative herdmates belonging to eight Italian Nor98 scrapie outbreaks. The results revealed that histidine at codon 154 is also strongly associated with the disease in goats.

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Year:  2008        PMID： 19008408     DOI： 10.1099/vir.0.2008/004150-0

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  21 in total

1.  Analysis of genetic variability at codon 42 within caprine prion protein gene in relation to production traits in Chinese domestic breeds.

Authors:  Xianyong Lan; Haiyu Zhao; Chongyang Wu; Shenrong Hu; Chuanying Pan; Chuzhao Lei; Hong Chen
Journal:  Mol Biol Rep       Date:  2011-12-10       Impact factor: 2.316

2.  Role of the goat K222-PrP(C) polymorphic variant in prion infection resistance.

Authors:  Patricia Aguilar-Calvo; Juan Carlos Espinosa; Belén Pintado; Alfonso Gutiérrez-Adán; Elia Alamillo; Alberto Miranda; Irene Prieto; Alex Bossers; Olivier Andreoletti; Juan María Torres
Journal:  J Virol       Date:  2013-12-18       Impact factor: 5.103

3.  PRNP gene polymorphisms in main indigenous Turkish goat breeds.

Authors:  Iraz Akis; Kemal Oztabak; Gizem Atmaca; Feraye Esen Gursel; Atila Ates; Hasret Yardibi; Sema Gurgoze; M Hanifi Durak; Ibrahim Erez; Cemal Un
Journal:  Trop Anim Health Prod       Date:  2019-10-19       Impact factor: 1.559

4.  Genetic resistance to scrapie infection in experimentally challenged goats.

Authors:  Caroline Lacroux; Cécile Perrin-Chauvineau; Fabien Corbière; Naima Aron; Patricia Aguilar-Calvo; Juan Maria Torres; Pierrette Costes; Isabelle Brémaud; Séverine Lugan; François Schelcher; Francis Barillet; Olivier Andréoletti
Journal:  J Virol       Date:  2013-11-27       Impact factor: 5.103

5.  A cross-sectional study of PRNP gene in two native Sicilian goat populations in Italy: a relation between prion gene polymorphisms and scrapie incidence.

Authors:  Sergio Migliore; Stefano Agnello; Salvatore D'Avola; Wilfred Goldmann; Vincenzo Di Marco Lo Presti; Maria Vitale
Journal:  J Genet       Date:  2017-06       Impact factor: 1.166

6.  Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy.

Authors:  Laura Pirisinu; Romolo Nonno; Elena Esposito; Sylvie L Benestad; Pierluigi Gambetti; Umberto Agrimi; Wen-Quan Zou
Journal:  PLoS One       Date:  2013-06-24       Impact factor: 3.240

7.  Effects of polymorphisms in ovine and caprine prion protein alleles on cell-free conversion.

Authors:  Martin Eiden; Elizabeth Ortega Soto; Thomas C Mettenleiter; Martin H Groschup
Journal:  Vet Res       Date:  2011-02-15       Impact factor: 3.683

8.  Detection of four novel polymorphisms in PrP gene of Pakistani sheep (Damani and Hashtnagri) and goats (Kamori and Local Hairy) breeds.

Authors:  Amjed Hussain; Masroor E Babar; Muhammad Imran; Ikram U Haq; Muhammad M Javed
Journal:  Virol J       Date:  2011-05-20       Impact factor: 4.099

Review 9.  State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology.

Authors:  Gabriele Vaccari; Cynthia H Panagiotidis; Cristina Acin; Simone Peletto; Francis Barillet; Pierluigi Acutis; Alex Bossers; Jan Langeveld; Lucien van Keulen; Theodoros Sklaviadis; Juan J Badiola; Olivier Andreéoletti; Martin H Groschup; Umberto Agrimi; James Foster; Wilfred Goldmann
Journal:  Vet Res       Date:  2009-05-28       Impact factor: 3.683

10.  Genetic Variation in the Prion Protein Gene (PRNP) of Two Tunisian Goat Populations.

Authors:  Samia Kdidi; Mohamed Habib Yahyaoui; Michela Conte; Barbara Chiappini; Mohamed Hammadi; Touhami Khorchani; Gabriele Vaccari
Journal:  Animals (Basel)       Date:  2021-05-31       Impact factor: 2.752
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