Literature DB >> 19007822

Getting a grip on Thy-1 signaling.

Thomas H Barker1, James S Hagood.   

Abstract

A recent study by Hermosilla et al. [T. Hermosilla, D. Munoz, R. Herrera-Molina, A. Valdivia, N. Munoz, S.U. Nham, P. Schneider, K. Burridge, A.F. Quest, L. Leyton, Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication, Biochim Biophys Acta 1783 (2008) 1111-1120] demonstrates that Thy-1 on neurons binds to alphavbeta3 integrin on astrocytes via a conserved RLD motif, triggering the formation of focal adhesions and stress fibers via tyrosine phosphorylation and RhoA activation. This study adds to growing evidence regarding the signaling mechanisms and biological roles of Thy-1, an important regulator of context-dependent signaling. As knowledge of Thy-1 approaches its fiftieth year, it is critical to begin to synthesize insights from different fields to determine how this heretofore enigmatic molecule modulates cell behavior in both cis and trans.

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Year:  2008        PMID： 19007822      PMCID： PMC2701903          DOI： 10.1016/j.bbamcr.2008.10.004

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  22 in total

1.  Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites.

Authors:  L Leyton; P Schneider; C V Labra; C Rüegg; C A Hetz; A F Quest; C Bron
Journal:  Curr Biol       Date:  2001-07-10       Impact factor: 10.834

2.  Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum.

Authors:  A Saalbach; T Wetzig; U F Haustein; U Anderegg
Journal:  Cell Tissue Res       Date:  1999-11       Impact factor: 5.249

3.  Thy-1 and AvGp50 signal transduction complex in the avian nervous system: c-Fyn and G alpha i protein association and activation of signalling pathways.

Authors:  R C Henke; G S Seeto; P L Jeffrey
Journal:  J Neurosci Res       Date:  1997-09-15       Impact factor: 4.164

Review 4.  Thy-1: more than a mouse pan-T cell marker.

Authors:  S M Mansour Haeryfar; David W Hoskin
Journal:  J Immunol       Date:  2004-09-15       Impact factor: 5.422

5.  The structural motif glycine 190-valine 202 of the fibrinogen gamma chain interacts with CD11b/CD18 integrin (alpha M beta 2, Mac-1) and promotes leukocyte adhesion.

Authors:  D C Altieri; J Plescia; E F Plow
Journal:  J Biol Chem       Date:  1993-01-25       Impact factor: 5.157

6.  Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18).

Authors:  Anne Wetzel; Triantafyllos Chavakis; Klaus T Preissner; Michael Sticherling; Uwe-Frithjof Haustein; Ulf Anderegg; Anja Saalbach
Journal:  J Immunol       Date:  2004-03-15       Impact factor: 5.422

7.  The Thy-1/Thy-1 ligand interaction is involved in binding of melanoma cells to activated Thy-1- positive microvascular endothelial cells.

Authors:  A Saalbach; G Hildebrandt; U-F Haustein; U Anderegg
Journal:  Microvasc Res       Date:  2002-07       Impact factor: 3.514

8.  Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity.

Authors:  Thomas H Barker; Hernan E Grenett; Mark W MacEwen; Samuel G Tilden; Gerald M Fuller; Jeffrey Settleman; Anne Woods; Joanne Murphy-Ullrich; James S Hagood
Journal:  Exp Cell Res       Date:  2004-05-01       Impact factor: 3.905

9.  Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation.

Authors:  Thomas H Barker; Manuel A Pallero; Mark W MacEwen; Samuel G Tilden; Anne Woods; Joanne E Murphy-Ullrich; James S Hagood
Journal:  J Biol Chem       Date:  2004-03-18       Impact factor: 5.157

10.  Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked proteins: toward establishing rules governing the lateral mobility of membrane proteins.

Authors:  F Zhang; B Crise; B Su; Y Hou; J K Rose; A Bothwell; K Jacobson
Journal:  J Cell Biol       Date:  1991-10       Impact factor: 10.539
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  35 in total

Review 1.  Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype.

Authors:  John E Bradley; Gustavo Ramirez; James S Hagood
Journal:  Biofactors       Date:  2009 May-Jun       Impact factor: 6.113

2.  ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.

Authors:  Mauricio Henríquez; Rodrigo Herrera-Molina; Alejandra Valdivia; Alvaro Alvarez; Milene Kong; Nicolás Muñoz; Verónica Eisner; Enrique Jaimovich; Pascal Schneider; Andrew F G Quest; Lisette Leyton
Journal:  J Cell Sci       Date:  2011-05-01       Impact factor: 5.285

3.  A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.

Authors:  Haihui Lu; Karl R Clauser; Wai Leong Tam; Julia Fröse; Xin Ye; Elinor Ng Eaton; Ferenc Reinhardt; Vera S Donnenberg; Rohit Bhargava; Steven A Carr; Robert A Weinberg
Journal:  Nat Cell Biol       Date:  2014-09-28       Impact factor: 28.824

4.  Relevance of meniscal cell regional phenotype to tissue engineering.

Authors:  Shawn P Grogan; Chantal Pauli; Martin K Lotz; Darryl D D'Lima
Journal:  Connect Tissue Res       Date:  2016-12-07       Impact factor: 3.417

5.  CD90 positive cells exhibit aggressive radioresistance in esophageal squamous cell carcinoma.

Authors:  Yuandong Wang; Chi Zhang; Hongcheng Zhu; Junwei Tang; Shu Zhang; Jinhua Luo; Xinchen Sun
Journal:  J Thorac Dis       Date:  2017-03       Impact factor: 2.895

6.  Prions disturb post-Golgi trafficking of membrane proteins.

Authors:  Keiji Uchiyama; Naomi Muramatsu; Masashi Yano; Takeshi Usui; Hironori Miyata; Suehiro Sakaguchi
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

7.  Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4.

Authors:  Milene Kong; Nicolás Muñoz; Alejandra Valdivia; Alvaro Alvarez; Rodrigo Herrera-Molina; Areli Cárdenas; Pascal Schneider; Keith Burridge; Andrew F G Quest; Lisette Leyton
Journal:  Biochim Biophys Acta       Date:  2013-02-26

8.  Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis.

Authors:  David M Wong; Vivian Tam; Roselind Lam; Katrina A Walsh; Liliana Tatarczuch; Charles N Pagel; Eric C Reynolds; Neil M O'Brien-Simpson; Eleanor J Mackie; Robert N Pike
Journal:  Infect Immun       Date:  2009-11-23       Impact factor: 3.441

9.  Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.

Authors:  Michelle L Churchman; Jonathan Low; Chunxu Qu; Elisabeth M Paietta; Lawryn H Kasper; Yunchao Chang; Debbie Payne-Turner; Mark J Althoff; Guangchun Song; Shann-Ching Chen; Jing Ma; Michael Rusch; Dan McGoldrick; Michael Edmonson; Pankaj Gupta; Yong-Dong Wang; William Caufield; Burgess Freeman; Lie Li; John C Panetta; Sharyn Baker; Yung-Li Yang; Kathryn G Roberts; Kelly McCastlain; Ilaria Iacobucci; Jennifer L Peters; Victoria E Centonze; Faiyaz Notta; Stephanie M Dobson; Sasan Zandi; John E Dick; Laura Janke; Junmin Peng; Kiran Kodali; Vishwajeeth Pagala; Jaeki Min; Anand Mayasundari; Richard T Williams; Cheryl L Willman; Jacob Rowe; Selina Luger; Ross A Dickins; R Kiplin Guy; Taosheng Chen; Charles G Mullighan
Journal:  Cancer Cell       Date:  2015-08-27       Impact factor: 31.743

Review 10.  The adventitia: essential regulator of vascular wall structure and function.

Authors:  Kurt R Stenmark; Michael E Yeager; Karim C El Kasmi; Eva Nozik-Grayck; Evgenia V Gerasimovskaya; Min Li; Suzette R Riddle; Maria G Frid
Journal:  Annu Rev Physiol       Date:  2012-12-03       Impact factor: 19.318
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